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Rab蛋白调控胞内囊泡运输 被引量：2

Rab GTPases Regulate Vesicle Traffic
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摘要 细胞内各个细胞器之间通过囊泡的膜转运是真核细胞存在的基本。Rab蛋白确保了转运蛋白被运输至正确的目的地。Rab蛋白是小GTP酶中的一大家族,它通过募集其效应物蛋白,其中包括接头蛋白,栓系因子,激酶,磷酸酶以及动力蛋白等,调控了细胞膜的选取,囊泡出芽,去包被,转运以及膜融合等过程。本文主要从Rab蛋白循环着手,依次论述了Rab蛋白在囊泡出芽,去包被,转运和膜融合等过程中起到的作用,从而使读者对Rab蛋白能有一个更加系统的了解。 Rab GTPases is a large family of small GTPases.Rab GTPases regulate vesicle traffic which is fundamental to the existence of eukaryotic cells.Rab GTPases recruit their effect proteins including sorting adaptors,tethering factors,kinases,phosphatases and motors,control membrane identity and vesicle budding,uncoating,motility and fusion.This paper introduced the circuitry of Rab GTPases and their function in vesicle budding,uncoating,motility and fusion.
作者 冯婉娟 徐子静 孟令锋 张蓉颖
机构地区 华中科技大学生命科学与技术学院
出处 《现代生物医学进展》 CAS 2012年第13期2582-2584,2600,共4页 Progress in Modern Biomedicine
基金 科技部国家重大科学研究计划蛋白质专项资助项目(2011CB910402) 国家自然科学基金资助项目(31071249)
关键词 RAB蛋白 囊泡运输 囊泡出芽 去包被 转运 膜融合 Rab GTPases Vesicle traffic Vesicles budding Uncoating Motility and fusion
分类号 Q291 [生物学—细胞生物学] Q75 [生物学—分子生物学]
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参考文献43

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同被引文献25

  • 1郭志爱,臧庆伟,景蕊莲,赵军,昌小平,李润植,赵志立.小麦小G蛋白Rab2基因TaRab2的克隆及其表达分析[J].作物学报,2007,33(2):201-207. 被引量：8
  • 2Jia Y, Xue L, Li J, et al. Isolation and proteomie analysis of the halo- tolerant alga Dunaliella salina flagella using shotgun strategy [J] . Mol Biol Rep, 2010, 37 ( 2 ) : 711-716.
  • 3Goyal A. Osmoregulation in Dunaliella, Part II : Photosynthesis and starch contribute carbon for glycerol synthesis during a salt stress in Dunaliella tertiolecta [ J ] . Plant Physiol Biochem, 2007, 45 ( 9 ) : 705 -710.
  • 4Mazel A, Leshem Y, Tiwari BS, et al. Induction of salt and osmotic stress tolerance by overexpression of an intracellular vesicle trafficking protein AtRab7 ( AtRabG3e ) [ J ] . Plant Physiol, 2004, 134 ( 1 ) : 118-128.
  • 5Nahm MY, Kim SW, Yun D, et al. Molecular analyses of OsRab7, a rice Rab7 homolog [ J ] . Plant Cell Physiol, 2003, 44 ( 12 ) : 1341-1349.
  • 6Grosshans BL, Ortiz D, Novick P. Rabs and their effectorsachieving specificity in membrane traffic [ J ] . Proc Natl Acad Sci USA, 2006, 103 ( 32 ) : 11821-11827.
  • 7Deneka M, Neeft M, van der Sluijs P. Regulation of membrane transport by Rab GTPases [ J ] . Crit Rev Biochem Mol Biol, 2003, 38 ( 2 ) : 121-142.
  • 8Eathiraj S, Pan X, Ritacco C, et al. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5[ J ]. Nature, 2005, 43( 6 ): 415-419.
  • 9Coxon FP, Rogers MJ. The role of prenylated small GTP-bindingproteins in the regulation of osteoclast function [ J l : Calcif Tissue Int, 2003, 72 : 80-84.
  • 10Agarwal PK, Agarwal P, Jain P, et al. Constitutive overexpression of a stress-inducible small GTP-binding protein PgRab7 from Pennisetum glaucum enhances abiotic stress tolerance in transgenic tobacco [ J ] . Plant Cell Rep, 2008 27 : 105-115.

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现代生物医学进展
2012年 第13期

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