银杏内酯B诱导大鼠骨髓间充质细胞分化为神经元样细胞的电生理研究

Electrophysiology Study on Differentiation of Rat Bone Marrow Stromal Stem Cells into Neurom-like Cells by Ginkgolide B

目的:研究银杏内酯B(GB)诱导大鼠骨髓间充质细胞(MSCs)分化为神经元样细胞的电生理特性。方法:应用膜片钳技术,采用全细胞记录方式,对由GB诱导的大鼠MSCs进行诱导前后的电生理功能测定。结果:分化后的神经元样细胞较诱导前细胞的膜特性有了显著改变(P<0.05)。结论:大鼠MSCs经过GB诱导能够向功能性神经元方向分化。

Objective： To investigate the elctrophysiological properties of differentiation of rat bone marrow stroma cell（MSCs） induced by Ginkgolide B（GB）.Methods： Elctrophysiologica functions of rat MSCs before and after differentiating into neurons-like cells were induced by GB.Results： The membrance properties changed a lot between differerntiated cell and undifferentiated neuron-like cell（P〈0.05）.Conclusion： MSCs can differentiate into functional neurons if induced by GB.