血管内皮生长因子及其受体在大肠癌中的表达

Expression of Vascular Endothelial Growth Factor and its Receptor in Human Colorectal Carcinoma and its Prognostic Significance

研究血管内皮生长因子（ＶＥＧＦ）及其受体（ＫＤＲ）在大肠癌中的表达及其临床意义。［方法］应用免疫组化ＳＰ 法检测１５５ 例大肠癌标本ＶＥＧＦ及ＫＤＲ蛋白的表达。分析ＶＥＧＦ和ＫＤＲ与临床病理因素、微血管计数（ＭＶＣ）及预后的关系。［结 果〕ＶＥＧＦ和ＫＤＲ的表达与大肠癌浸润深度、淋巴结转移、血管侵犯、肝脏转移、Ｄｕｋｅｓ’分期密切相关，而与组织学分型和肿瘤大小 无关。ＶＥＧＦ和ＫＤＲ的表达密切相关。ＶＥＧＦ和ＫＤＲ表达阳性者ＭＶＣ显著高于阴性者。ＶＥＧＦ阳性者预后较阴性者明显为差。 ［结论］ＶＥＧＦ和ＫＤＲ与大肠癌血管生成有关，促进了大肠癌的侵袭和转移。 ＶＥＧＦ是大肠癌病人一个较好的预后指标。

Purpose]To investigate the expression of vascular endothelial growth factor(VEGF) and its receptor(KDR) as well as their clinical significance in human colorectal carcinoma. [Methods] The expression of VEGF and KDR in paraffin-embedded sections from 155 patients with human colorectal carcinome were measured by immunohistochemical staining. The expression of VEGF and KDR were analysed with relation to various clinicopathologic factors, MVC and prognosis of colorectal carcinoma. [Results]The expression of VEGF and KDR positively correlated with depth of invasion, lymph-node metastasis, vessel invasion, liver metastasis and Dukes' stage, but their relation to the histologic types and tumor size was not significant. VEGF expression positively correlated with KDR expression. MVC was significantly higher in VEGF-postive and KDR-positive. Patients with VEGF-positive had a significantly worse prognosis than those with VEGF-negative tumors. [ Conclusion ] VEGF and KDR are highly related to angiogenesis of colorectal carcinoma and promote invasion and metastasis of colorectal carainoma. VEGF may be a better rognostic marer for patients with colorectal carcinoma.