氟铁龙与氟脲嘧啶治疗晚期消化道癌的疗效比较

Comparison of the therapeutic effects of 5′-DFUR and 5-Fu on advanced digestive tract cancer

目的 比较氟铁龙与氟脲嘧啶对晚期消化道癌的疗效。方法 42例晚期消化道癌随机分为治疗组和对照组 ,治疗组用氟铁龙加丝裂霉素化疗 ,对照组用氟脲嘧啶加丝裂霉素化疗。 2～ 3周期后评价疗效与毒副反应。结果 治疗组有效率为 61.9% ,对照组为 3 8.1%。两组差异无显著性。两组毒副反应均表现为白细胞下降与恶心、呕吐等 ,差异无显著性。结论 氟铁龙加丝裂霉素联合化疗 ,对晚期消化道癌是一疗效较高和较安全的方案。

Objective To compare the efficacy of 5′ DFUR with that of 5 Fu in advanced digestive tract cancer.Methods Foryt two cases of advanced digestive tract cancer were randomized to two chemotherapy groups,namely the 5 DFUR+MMC group and the 5 Fu+MMC group.Patients who completed at least 2 cycles were evaluated.Results The response rate was 61.9% for 5′ DFUR,and 38.1% for 5 Fu,however there was no statistical significant difference between the two groups( P >0.05).The main side effects included leucopenia,nausea and vomiting;no significant difference between the two groups was noted.Conclusion 5′ DFUR+MMC is an effective regimen for patients with advanced digestive tract cancer.