彝族和汉族男性ACE基因多态性与高血压关系的研究

A study on the association between hypertension and polymorphism of the ACE gene in Yi and Han people in Liangshan Yi people Autonomous Prefecture

应用横断面研究方法和PCR等实验技术 ,探讨彝族和汉族人群血管紧张素转换酶 (ACE)基因多态性与高血压的关系。结果表明 ,彝族男性高血压和正常血压者ACE基因DD型所占比例分别是 9 7%和 13 0 % ,ID型分别是 48 4%和5 0 9% ,II型分别是 41 9%和 36 1%。Ⅰ等位基因频率分别是 6 6 1%和 6 1 6 % ,D等位基因频率分别是 33 9%和38 4%。汉族男性高血压和正常血压者DD型所占比例分别是 12 3%和 11 2 % ,ID型分别是 5 0 8%和 49 5 % ,II型分别是 36 9%和 39 3%。Ⅰ等位基因频率分别是 6 2 3%和6 4 0 % ,D等位基因频率分别是 37 7%和 36 0 %。未发现彝族和汉族男性高血压和正常血压者之间的ACE基因型分布及I/D等位基因频率存在显著性差异 (P >0 0 5 ) ,故认为彝族和汉族男性ACE基因多态性与高血压的关联尚不能确定。

The study explored the association between hypertension and ploymorphism of the ACE gene in Yi and Han people with the cross-sectional survey and PCR technique.Among the male Yi people,the distribution of DD,ID and II genotypes for the ACE gene was 9 7% and 13 0%,48 4% and 50 9%,41 9% and 36 1%,respectively,in hypertensives and normotensives.Frequencies of I and D alleles for the ACE gene were 66 1% and 61 6%,33 9% and 38 4%,respectively,in hypertensives and normotensives.Among the male Han people,the distribution of DD,ID and II genotypes for the ACE gene was 12 3% and 11 2%,50 8% and 49 5%,36 9% and 39 3%,respectively,in hypertensives and normotensives.Frequencies of I and D alleles for the ACE gene were 62 3% and 64 0%,37 7% and 36 0%,respectively,in hypertensives and normotensives.There were no significant difference in the distribution of II,ID and DD genotypes and the frequencies of I/D alleles for the ACE gene between hypertensives and normotensives in the male Yi and Han people.The association between polymorphism of the ACE gene and hypertension was uncertainty among the studied population.