环境香烟烟雾和缺碘对大鼠微量元素代谢的联合作用

The Joint Action of Environmental Tobacco Smoke and Iodine Deficiency on the Metabolism of Trace Elements in Rats

采用析因实验设计 ,以尿碘含量显著减低 (P <0 0 5 )为标志的环境香烟烟雾 (ETS)和碘缺乏 (ID)双因素大鼠模型观察对微量元素的影响。结果发现 :产生协同效应有Se、I和Zn含量在甲状腺降低 ,Se和Zn含量在肝脏降低 ,而I和Cu含量增加 ,血中I含量下降。ETS因素使甲状腺I、Se和Zn含量均降低 ,肝脏Se和Cu含量下降 ,I含量增高 ,大脑Se和Zn含量降低 ;ID因素使甲状腺I、Se和Zn含量降低 ,肝Se和Li含量降低。Cu和Zn含量增加。提示 :ETS和ID联合作用 ,可引起多种微量元素代谢障碍 ,以Se和I贮备下降和利用异常变化为主。因此 ,补碘效果不明显时 。

The two factors factorial design principle was adopted to study the changes of trace elements in rats by founding the experimental model of environmental tobacco smoke(ETS),and iodine deficiency(ID).The results showed that the synergistic effect decreased the contents of Se,I,Zn in thyroid,Se Li in liver and Cu in serum.But the contents of I,Cu in liver were increased due to the joint action.Ant ETS factor decreased the contents of I,Se,Zn in thyroid,Se Zn in brain,but increased the content of I in liver.The contents of I,Se,Zn in thyroid,Se Li in liver were decreased and Cu,Zn in liver were increased by ID factor The result indicated that the joint action of ETS and ID can affect the metabolism of some trace elements,especially the normal storage and employmnet of Se and I.Therefore,it should be considered rationally when the result of making up for iodine is not very effective.