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Duration of viral shedding of Influenza A(H1N1) virus infection treated with oseltamivir and/or Traditional Chinese Medicine in China:A retrospective analysis 被引量:6

Duration of viral shedding of Influenza A(H1N1) virus infection treated with oseltamivir and/or Traditional Chinese Medicine in China:A retrospective analysis
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摘要 OBJECTIVE:H1N1 was a new and potentially serious infectious disease,in human,the severity of influenza can vary from mild to severe,thus to find an effective and safety way to control the influenza pandemic is of crucial importance.This retrospective study describes the duration of viral shedding in H1N1 patients that were hospitalized and treated in China.METHODS:Clinical data were collected from May to July,2009 in China for 963 patients with influenza A(H1N1) virus infection.Patients were treated based on the guidelines issued by the Chinese Ministry of Health.The primary outcome was duration of viral shedding and statistical comparisons were performed.RESULTS:In the patients with body temperature greater than 38.0℃,there were no differences in virus shedding duration among the patients taking oseltamivir within two days,patients undergoing Traditional Chinese Medicine(TCM) therapy or those receiving no drug therapy.In patients with body temperature 338.1℃,TCM therapy reduced the viral shedding duration(P<0.05,vs.oseltamivir therapy).Furthermore,taking oseltamivir two days after onset of symptoms might prolong the virus shedding duration(P<0.05,vs.taking oseltamivir less than 2 days of onset).CONCLUSION:TCM therapy is effective for reducing the length of virus shedding in patients with body temperature 338.0℃.Oseltamivir used for reducing virus shedding duration should be taken within two days of onset. OBJECTIVE:H1N1 was a new and potentially serious infectious disease,in human,the severity of influenza can vary from mild to severe,thus to find an effective and safety way to control the influenza pandemic is of crucial importance.This retrospective study describes the duration of viral shedding in H1N1 patients that were hospitalized and treated in China.METHODS:Clinical data were collected from May to July,2009 in China for 963 patients with influenza A(H1N1) virus infection.Patients were treated based on the guidelines issued by the Chinese Ministry of Health.The primary outcome was duration of viral shedding and statistical comparisons were performed.RESULTS:In the patients with body temperature greater than 38.0℃,there were no differences in virus shedding duration among the patients taking oseltamivir within two days,patients undergoing Traditional Chinese Medicine(TCM) therapy or those receiving no drug therapy.In patients with body temperature 338.1℃,TCM therapy reduced the viral shedding duration(P〈0.05,vs.oseltamivir therapy).Furthermore,taking oseltamivir two days after onset of symptoms might prolong the virus shedding duration(P〈0.05,vs.taking oseltamivir less than 2 days of onset).CONCLUSION:TCM therapy is effective for reducing the length of virus shedding in patients with body temperature 338.0℃.Oseltamivir used for reducing virus shedding duration should be taken within two days of onset.
出处 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2012年第2期148-155,共8页 中医杂志(英文版)
基金 Supported by the projects from the State Administration of Traditional Chinese Medicine (200907001) National Science Foundation of China (No. 30825047 and 90709007)
关键词 H1N1 Treatment of oseltamivir Treatment of TCM 病毒感染 药物治疗 传统医药 时间 中国 流感 A型 中医药疗法
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  • 1Health MoP. Notice on printing and distribution of Guidline of preventing and treating influenza A (H1N1) —The first edition of,2009Trial version.China[OL].http://www.moh.gov.cn/publicfiles/business/htmlfiles/mohyzs/s3585,2009 05/240478.htm,2010.
  • 2Cao B,Li XW,Mao Y,Wang J Lu HZ Chen YS Liang ZA Liang L Zhang SJ Zhang B Gu L Lu LH Wang DY Wang C. Clinical features of the initial cases of,2009pandemic influenza A (H1N1) virus infection in China[J].New England Journal of Medicine,2009.2507-2517.

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