摘要
目的 研究国产重组人生长激素（ｒｈＧＨ）治疗生长激素缺乏症（ＧＨＤ）的临床效果和安全性。方法ＧＨＤ６７例，年龄１１．９３±３．１８岁，身高１１８．４１±１４．３６ｃｍ，生长速率２．９５±０．８ｃｍ／ａ。给予国产ｒｈＧＨ，０．１Ｕ· ｋｇ－１· ｄ－１，疗程６月。结果 ｒｈＧＨ对患儿体格的线性生长有显著促进作用（Ｐ＜０．００１），完全性ＧＨＤ和部分性ＧＨＤ６个月的生长速率分别为１３．３６±３．７３ｃｍ／ａ和１０．３３ ± ２．２１ｃｍ／ａ，两者差别有高度显著性 （Ｐ＜０．０１）。结论 国产ｒｈＧＨ是一种治疗ＧＨＤ的有效药物，近期效果和进口的ｒｈＧＨ相似，并且完全性ＧＨＤ的疗效比部分性ＧＨＤ好。
Objective To evaluate the efficacy and safety of domestic recombinant human growth hormone (rhGH) in treating growth hormone deficiency (GHD). Methods 67 GHD children (age 11.93± 3.18 years, height 118.41 ± 14.36cm, height velocity 2.95±0.8cm/a) received domestic rhGH 0.1U· kg-1· d-1 for 6 months. Results The effect of increasing linear growth is significant (P<0.001) with complete GHD height velocity 13.36±3.73cm/a, and partial GHD 10.33±2.21cm/a. The difference is highly significant (P<0.01). Conclusion Domestic rhGH is effective in treating GHD; its recent efficacy is similar to the imported ones. It has a better result in complete GHD than in partial GHD.
出处
《上海第二医科大学学报》
CSCD
2000年第2期135-137,共3页
Acta Universitatis Medicinalis Secondae Shanghai
