摘要
目的 研究国产重组人生长激素(rhGH)治疗生长激素缺乏症(GHD)的临床效果和安全性。方法GHD67例,年龄11.93±3.18岁,身高118.41±14.36cm,生长速率2.95±0.8cm/a。给予国产rhGH,0.1U· kg-1· d-1,疗程6月。结果 rhGH对患儿体格的线性生长有显著促进作用(P<0.001),完全性GHD和部分性GHD6个月的生长速率分别为13.36±3.73cm/a和10.33 ± 2.21cm/a,两者差别有高度显著性 (P<0.01)。结论 国产rhGH是一种治疗GHD的有效药物,近期效果和进口的rhGH相似,并且完全性GHD的疗效比部分性GHD好。
Objective To evaluate the efficacy and safety of domestic recombinant human growth hormone (rhGH) in treating growth hormone deficiency (GHD). Methods 67 GHD children (age 11.93± 3.18 years, height 118.41 ± 14.36cm, height velocity 2.95±0.8cm/a) received domestic rhGH 0.1U· kg-1· d-1 for 6 months. Results The effect of increasing linear growth is significant (P<0.001) with complete GHD height velocity 13.36±3.73cm/a, and partial GHD 10.33±2.21cm/a. The difference is highly significant (P<0.01). Conclusion Domestic rhGH is effective in treating GHD; its recent efficacy is similar to the imported ones. It has a better result in complete GHD than in partial GHD.
出处
《上海第二医科大学学报》
CSCD
2000年第2期135-137,共3页
Acta Universitatis Medicinalis Secondae Shanghai