紫杉醇的毒性研究

Toxicity Study of Taxol

目的 研究大鼠连续５ｄ腹腔注射紫杉醇的毒性作用。方法 ８０只大鼠分４组，每组２０只，雌雄各半，剂量分别是１１．６、５．８、１．１６ｍａ／ｋｇ；另设溶剂对照组。分别在第８、３３ｄ各处死一半动物，测定血液生化、尿、病理等指标来判断其毒性作用。结果 紫杉醇的毒性主要表现在消化系统、免疫系统与骨髓抑制等。结论紫杉醇有明显的毒性作用，但其毒性是依赖剂量的，停药后可恢复。

Objective This investigation was to study the toxicity of taxol given intra peritoneally (iP) to rats for five consecutive days. Methods Four groups of rats, each consisting of 10 males and 10 females, were given taxol ip once a day for five days in doses of 11.6. 5.8 and 1.16mg/kg with the control group given an appropriate amount of some vehicle. Half of the rats were sacrificed on day & and 33 respectively. Hematological, blood chemical, urinary parameters were determined together with necropsy and histopathological studies to assess toxicity. Results The toxic effects of taxol were particularly in the liver, alimentary tract and immune system. Myelosuppresion was also present. The toxicity of taxol was dose -- dependent. Conclusion The toxicity of taxol was prominent but reversible.