太原市焦炉工人尿中多种羟基多环芳烃浓度水平

Concentration of urinary hydroxy polycyclic aromatic hydrocarbons in coke oven workers in Taiyuan City

以我国北方城市—太原市60名焦炉工人(男女人数比为2:1,年龄:40～50岁)为研究人群,分别在采暖期(2009年12月)和非采暖期(2009年9月)收集其工作8h的班前和班后尿液,同时以该市郊区60名农民为对照组,并统一采用问卷的方式收集其年龄、性别、工种、职业史、疾病史等信息,通过酶水解-高效液相色谱法分析测定尿样中6种OH-PAHs的浓度水平.该焦炉工人尿液中2-OHNap、2-OHFlu、3-OHPhe、9-OHPhe、1-OHPy和3-OHBap的平均浓度水平均高于对照组,分别为19.83、5.63、2.05、1.75、1.67和0.23μmol/mol肌酐,各OH-PAHs的浓度水平依次为2-OHNap>2-OHFlu>∑-OHPhe(3-OHPhe+9-OHPhe)>1-OHPy>3-OHBap;男性尿液中OH-PAHs的浓度水平高于女性,采暖期的浓度水平高于非采暖期,但季节差异不大;焦炉工人尿中各OH-PAHs的浓度水平呈炉顶工>炉侧工>炉底工>对照组的趋势;焦炉工人在8h班后尿中各OH-PAHs的浓度水平均高于班前水平,其中高环的3-OHBap的浓度增加量最高,比班前增加了55%.焦炉工人尿液中的OH-PAHs的浓度水平与外暴露存在着正比关系,因此,建议进一步开展焦炉工人外暴露水平和内暴露水平之间关系的研究.

60 coke oven workers（F/M=2：1,age： 40～50） from Taiyuan,Shanxi province were recruited and their urine samples were collected before and after 8h work in heating（December 2009） and non-heating season（September 2009）,respectively,with 60 farmer as control group.Informations on their age,gender,and others were gathered by a unified questionnaire.Concentration levels of 6OH-PAHs in urine samples were determined by enzymatic hydrolysis-high-performance liquid chromatography.The average concentration of 2-hydroxynaphthalene（2-OHNap）,2-hydroxyfluorene（2-OHFlu）,3-hydryxyphenanthrene（3-OHPhe）,9-hydryxyphenanthrene（9-OHPhe）,1-hydroxypyrene（1-OHPy） and 3-hydroxybenzo（a）pyrene（3-OHBaP） were 19.83,5.63,2.05,1.75,1.67and 0.23μmol/mol creatinine in coke oven workers.The trend of OH-PAHs concentration level was in order of 2-OHNap 2-OHFlu Σ-OHPhe（3-OHPhe ＋9-OHPhe） 1-OHPy 3-OHBap;the levels of men were higher than that of women,and the levels in heating period were higher than that in non-heating period.Concentrations trend of urinary OH-PAHs level was top side workers side oven workers bottom side workerscontrol group,which was adjust for external exposure categories.Concentrations of OH-PAHs after 8hours work were higher than the levels before work,and 3-OHBap had the most greatly increase by 55%.The results show that there was a proportional relationship between urinary concentrations of OH-PAHs and external exposure levels of coke oven workers.Therefore,further research of the relationship between external and internal exposure levels of coke oven workers is recommended.