血压变异性与脑白质疏松相关性的初步研究

Relationship between Blood pressure bariabiliy and Leukoaraiosis

目的探讨血压变异性与脑白质疏松的相关性。方法选取86例上海友谊社区2010年1月～2011年3月就诊患者，根据颅脑磁共振的结果分为脑白质疏松组43例及非脑白质疏松组43例，收集患者动态血压检查结果：（1）24小时平均收缩压（24hSBP）、24小时平均舒张压（24hDBP）及相应标准差；（2）白昼平均收缩压（dSBP），白昼平均舒张压（dDBP）及相应标准差；（3）夜间平均收缩压（nSBP）、夜间平均舒张压（nDBP）及相应标准差。血压变异性计算：以相应时段的动态血压标准差除以动态血压的平均值所得的变异分数表示。结果脑白质疏松组血压变异性均显著高于非脑白质疏松组，差异有统计学意义（P〈0．01）。结论血压变异性与脑白质疏松关系密切。

Objective To explorer the effects of blood pressure bariabiliy on leukoaraiosis. Methods We recruited 86 patients with leukoaraiosis （LA） and non-leukoaraiosis （non-LA） who were hospitalized in youyi communtiy between January 2010 to March 2011 ,the number of cases in LA group were 43, and non-LA group were 43. According to the 24 h blood pressure monitoring We collect the dates ： （ 1 ） 24hSBP,24hDBP,24hSBPSD, 24hDBPSD. （2） dSBP, dDBP, dSBPSD, dDBPSD. （ 3 ） nSBP, nD- BP, nSBPSD, nDBPSD. Computing of blood pressure bariabiliy ： It is figured in BPV that SD of ABP divises mean of ABP correspond to period of time. For example 24hSBPV = 24hSBPSD/24hSBP. Results The simple factor analysis showed that blood pressure bariabiliy in LA group were significant higher than non- LA group and the data showed a statistical significance （ P 〈 0.01 ）. Conclusion The study proves that there is significantly correlation between blood pressure bariabiliy and leukoaraiosis.