针刺对慢性关节炎大鼠痛反应迟钝及其脊髓内P-物质含量的影响

Effects of Acupuncture on the Pain Perceptive Numbness and the Content of SP in the Spinal Cord of Adjuvant Chronic Arthritic Rat

痛反应是一种生理性的防御机能,但异常的痛觉过敏或迟钝则是病理现象。临床上许多慢性关节炎患者常常有痛觉异常或麻木感,在慢性关节炎大鼠的关节局部也出现痛反应迟钝的现象,因此,我们用慢性关节炎大鼠为模型,

In this study,we have researched the relationof efficacy of acupuncture on the pain perceptivenumbness to the content of SP(substance P)in thelumbar spinal cord of adjuvant chronic arthritic rat.Results:(1)We discovered that the average painthreshold of chronic arthritic rats(21 days aftersuffering from arthritis)was 305%,as comparedwith that of the normal rats,that is called the painperceptive numbness.While the pain threshold ofarthritic rats treated with acupuncture was 203%only.The former was much more than the latter(P<0.01).This suggests that the acupuncture mightevidently regulate the pain perceptive numbness ofchronic arthritic rats.(2)The average content ofSP in the lumbar spinal cord of chronic arthriticrats was 6.92±0.27 p mole/10 mg wet tissue,ascompared with the normal value(8.56±0.64 p mole/10 mg wet tissue),it was decreased significantly(P<0.05).But the content of Sp in the lumbarspinal cord of arthritic rats treated with acupuncturewas 16.00±1.65 p mole/10 mg wet tissue,it wasmuch more than that of the chronic arthritic rats.