乙氧萘青霉素钠中间体2-乙氧基-萘醛制备工艺中Vilsmeier反应的绿色改进

Green modification on synthesis of 2-ethoxy-1-naphthaldehyde

以β-萘酚为原料,经醚化和Vilsmeier反应,合成了乙氧萘青霉素钠的侧链合成中间体2-乙氧基-萘醛,总收率90.2%,并对第二步Vilsmeier反应的合成工艺进行了改进,提高了收率,降低了废液的总磷、总氮和总量,提高了反应的环境友好性。

2-Ethoxy-l-naphthaldehyde was synthesized from 2-naphthol through etherification and Vils- meier reaction in an over all yield of 90.2%. The 2nd step, Vilsmeier reaction was improved with result of lower total nitrogen, lower total phosphorus, lower amount and being much more environment friendly.