Ki67在不同分子类型乳腺癌组织中的表达及意义

Significance of Ki67 Expression in Different Molecular Classifications of Breast Cancer

目的探讨Ki67在不同分子类型乳腺癌组织中的表达及临床意义。方法采用免疫组织化学法,检测368例乳腺癌组织标本中Ki67表达情况,采用Wilcoxon秩和检验分析Ki67在不同分子类型乳腺癌组织中的表达差异;采用Spearman秩相关方法,分析Ki67表达与原发肿瘤大小、腋窝淋巴结转移及病理分期等的相关性。结果 Lumina型、Her-2型及三阴型乳腺癌组织中Ki67表达强度无显著性差异(χ2=0.015,P=0.993);Ki67表达强度与Lumina型乳腺癌的原发肿瘤大小、腋窝淋巴结转移及病理分期呈正相关性(γs=0.167,P=0.013;γs=0.142,P=0.035;γs=0.165,P=0.014),而与Her-2型及三阴型乳腺癌的以上3个病理因素无显著性相关(P>0.05)。结论在Lumina型、Her-2型及三阴型乳腺癌组织中Ki67表达强度无显著性差异,Ki67表达强度与Lumina型乳腺癌的临床病理因素相关,是Lumina型乳腺癌的不良预后因素。

Objective To investigate the difference of Ki67 expression in three molecular classifications of breast cancer and clinic significance. Methods The Ki67 expression was detected in 368 eases of breast cancer tissue specimen by immuno- histoehemistry（IHC） ,The difference of Ki67 expression was analyzed by Wileoxon rank sum test among three molecular classifi- cations of breast cancer tissues ; its correlation with primary tumor diameter （ PTD）, axillary lymph node （ ALN ） metastasis and pathological stage were analyzed by Spearman rank correlation. Results The difference of Ki67 expression was not significant a- mong the Lumina type, Her-2 type, triple-negative （TN） type breast cancer tissues （ X2 = 0.015, P = 0. 993 ） ;The intensity of Ki67 expression was correlate with PTD ,ALN metastasis and pathological stage in Lumina type breast cancer （γs =0. 167 ,P = 0. 013; γs =0. 142,P=0.035;γs =0. 165,P=0.014） ,while not in Her-2 type and TN type breast cancer. Conclusion The intensity of Ki67 expression was not siglificant among three molecular classifications of breast cancer,while it was related to clinic patholog- ical factors of Lumina type breast cancer significantly and Ki67was a poor prognostic factor of Lumina type breast cancer.