COX-2、CD4及CD8在胃癌组织中的表达及其意义

Express and Clinical Significance of COX-2,CD4 and CD8 in Gastric Carcinoma

目的探讨胃癌中COX-2、CD4及CD8表达的关系及意义。方法采用免疫组织化学SP法检测62例胃腺癌、22例腺上皮异型增生组织及20例正常胃组织中COX-2、CD4及CD8的表达,并分析其与临床病理特征的关系。结果腺癌组织与腺上皮异型增生组织的COX-2表达高于正常胃组织,差异有统计学意义(P<0.05);腺癌组织与腺上皮异型增生组织的CD4、CD8表达低于正常胃上皮组织,差异有统计学意义(P<0.05);胃癌中淋巴结转移者及分化较低者COX-2表达低(P<0.05);COX-2与CD4及CD8的表达呈负相关。结论 COX-2高表达可能是胃癌变过程中的早期事件。COX-2促进胃癌变过程可能与其抑制机体免疫反应有关。

Objective This study was to investigate the clinical significance of expression and relationship of COX-2, CD4 and CD8 in gastric carcinoma. Methods The expression of COX-2 ,CIM and CD8 in 62 specimens of gastric carcinoma,22 specimens of adenoma dysplasia, and 20 specimens of normal gastric tissue was examined by SP immunohistoehemistry. Their cor- relations to clinicopathologic features of gastric carcinoma were analyzed. Results The protein level of COX-2 was significantly higher in gastric carcinoma and gastric dysplasia than in normal gastric tissue. The protein level of CD4 and CD8 was significantly lower in gastric carcinoma and gastric dysplasia than in normal gastric tissue. In gastric carcinoma, COX-2 expression was correla- ted to lymph node metastasis and differentiation （ P 〈 0.05 ）. COX-2 expression was negatively correlated to CD4 and CD8 expres- sion in gastric carcinoma. Conclusion The up-regulation of COX-2 may be correlated to the carcinogenesis of gastric tissue. COX-2 making carcinogenesis of gastric tissue may be correlated to body immunodepression.