人类免疫缺陷病毒血源传播问题的探讨

The serologic study on the blood transmission origin of HIV

目的 探讨人类免疫缺陷病毒 (HIV)血源传播来源问题。方法 收集全国各地HIV阳性血清 6 2份 ,其中献血员血清 2 7份 ,静脉吸毒者血清 35份 ,用EIA法进行HBV、HCV血清学检测。结果 HIV感染者HBV总感染率为 5 3.2 % (33/ 6 2 ) ;抗 -HCV阳性率为 95 .2 % (5 9/ 6 2 )。HIV、HBV、HCV三重感染率为 5 1.6 % (32 / 6 2 ) ,HIV、HCV和HIV、HBV二重感染率分别为 2 7.4% (17/6 2 )和 1.6 % (1/ 6 2 )。献血员中HBV总感染率 44 .4% (12 / 2 7) ,抗 -HCV阳性率 10 0 % (2 7/ 2 7) ;静脉吸毒者中HBV总感染率 6 0 .0 % (2 1/ 35 ) ,抗 -HCV阳性率 91.4% (32 / 35 )。经统计学处理 ,两人群HBV感染率与抗 -HCV阳性率差异无显著性 (P >0 .0 5 )。对两人群中HIV、HBV、HCV三重、双重、单一感染率分析发现 ,两人群间差异也无显著性 (P >0 .0 5 )。结论 结果提示 ,HIV感染献血员和HIV感染静脉吸毒者HCV感染率很高 ;两人群在感染HIV、HBV、HCV高危因素上存在着一定的内在联系 。

Objective To study the origin of HIV blood spread in China. Methods Markers of HBV and HCV in 62 HIV-infections sera (27 blood donors and 35 i.v.drug users) were detected by EIA. Results The results show that the total HBV infection was 53.2%(33/62) and anti-HCV positive 95.2 %(59/62).Super-infection of HIV、HBV、HCV was 51.6%(32/60) and super-infection of HIV、HCV and HIV、HBV were 27.4 %(17/62) and 1.6 %(1/62). Comparing the markers of HBV and anti-HCV between blood donors and i.v.drug users,there was no statistical significant difference( P > 0.05 ).The super- infection of HIV、HBV、HCV and HIV、HCV and HIV、HBV were also no statistical differences ( P > 0.05 ) between two groups. Conclusion Resnlts indicated that a common infection mechanism might exist between Chinese HIV- infection blood donors and i.v. drug users.