孟鲁司特钠佐治毛细支气管炎30例疗效观察

Montelukast in the Treatment of Bronchiolitis: A Report of 30 Cases

目的:观察口服孟鲁司特钠佐治毛细支气管炎的临床疗效。方法:60例毛细支气管炎患儿随机分为两组,治疗组30例,采用常规治疗加用孟鲁司特钠,年龄1.5～6个月孟鲁司特钠2 mg/d,6～20个月孟鲁司特钠4 mg/d,疗程4周;对照组30例,仅采用常规治疗。比较两组患儿疗效及症状、体征改善时间。结果:治疗组总有效率96.6%,高于对照组86.6%,两组比较差异有统计学意义(χ2=7.26,P<0.05)。治疗组气促缓解时间、哮鸣音消失时间、湿啰音消失时间、咳嗽消失时间均短于对照组,差异均有统计学意义(P<0.01)。结论:口服孟鲁司特钠辅助治疗毛细支气管炎疗效确切,且安全方便。

Objective：To observe the curative effect of montelukast in patients with bronchiolitis. Methods： Randomly 60 cases of infants with bronchiolitis were divided into two groups. The treatment group （n = 30 ） received conventional therapy in addition to montelukast 2 mg once daily in infants 1.5 - 6 months of age and 4 mg once daily in infants 6 - 20 months of age for four weeks. The control group （ n = 30） received routine therapy only. The effects were evaluated and compared. Results： The total effective rate of the treatment group （96.6%） was higher than that of the control group （86.6%）, the difference was significant （X2 = 7.26, P〈0.05 ）. Conclusions ： Oral administration of montelukast is effective, secure and convenient for bronchiolitis treatment.