羟基喜树碱联合透明质酸钠在膀胱癌术后膀胱灌注中的应用

The Effect of Hydroxycamptothecin Combined with Sodium Hyaluronate in Treatment of Postoperative Outpatients with Bladder Cancer

目的:探讨膀胱癌患者术后门诊行膀胱灌注羟基喜树碱联合透明质酸钠药物的作用效果。方法:对47例非肌层浸润膀胱尿路上皮癌患者行经尿道膀胱肿瘤电切术或行膀胱肿瘤膀胱部分切除术后行膀胱灌注。灌注时先将透明质酸钠40 mg加至30 mL生理盐水中灌注至膀胱,约15 min后再将羟基喜树碱20 mg加至40 mL生理盐水中灌注至膀胱。每次灌注后更换4个体位,每次保留药物约60 min。每周2次,10次为1个疗程。3个疗程后行膀胱镜检。结果:3例肿瘤复发,2例发生化学性膀胱炎,1例膀胱刺激症状较明显。结论:羟基喜树碱联合透明质酸钠行膀胱灌注不仅可以显著预防肿瘤复发,而且可以预防化学性膀胱炎的发生,提高患者的生活质量。

Objective： To investigate the drug effect of hydroxycamptothecin combined with sodium hyaluronate in postoperative outpatients with bladder cancer. Methods ：47 eases of superficial urothelial bladder carcinoma had bladder perfusion after transurethral resection or partial bladder resection of bladder tumor; perfused 40rag sodium hyaluronate ＋ 30ml saline in the bladder for 15min and then perfused the 20rag HCPT ＋ 40ml saline in the bladder, each perfusion was with replacement of the 4 kind of body position, each retaining the drug was 60 rain, two times per week, 10 times as a course of treatment. And had three courses of cystoscopy. Results： there were 3 cases of tumor recurred, 2 cases of chemical cystitis, 1 cases of bladder irritation symptoms. Conclusion： HCPT combined with sodium hyaluronate in the bladder perfusion can remarkably prevent tumor recurrence, and can prevent the occurrence of chemical cystitis, improve patients＇quality of lifeo