期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

葡萄糖转运因子1蛋白在肾癌组织中的表达及意义 被引量：2

下载PDF
导出
摘要 目的探讨葡萄糖转运因子1(Glut-1)蛋白在肾透明细胞癌发生、发展中的作用。方法采用免疫组化法检测50份肾透明细胞癌和10份同期距肾癌组织5 cm远的正常肾组织标本中Glut-1蛋白表达。结果 Glut-1蛋白在正常肾组织中无表达,在肾透明细胞癌组织中表达显著增强,阳性表达率为100%,但Glut-1表达与肾癌分级、分期无关。结论 Glut-1在肾癌组织中呈高表达,可能是参与肾癌发生的一个早期指标。
作者 熊升远 林毅 阮同德 傅强 张京东
机构地区 临沂市沂水中心医院 天津医科大学总医院 山东大学附属省立医院
出处 《山东医药》 CAS 2012年第23期44-45,共2页 Shandong Medical Journal
关键词 肾肿瘤 肾癌 葡萄糖转运因子1蛋白
分类号 R737.11 [医药卫生—肿瘤]
  • 相关文献

参考文献7

  • 1Furuta E,Okuda H,Kobayashi A. Metabolic genes in cancer:Their roles in tumor progression and clinical implications[J].Biochimica Et Biophysica Acta,2010,(02):141-152.
  • 2夏同礼.现代泌尿病理学[M]北京:人民卫生出版社,2002230-265.
  • 3Lasa M,Brook M,Saklatvala J. Dexamethasone destabilizes eyclooxygenase-2 mRNA by inhibitingmitogen-activated protein kinase p38[J].Molecular and Cellular Biology,2007,(21):771-780.
  • 4Mees G,Vangestel C,Dierckx R. Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma[J].Research in Veterinary Science,2011,(03):e125-e128.
  • 5Semaan A,Munkarah AR,Arabi H. Expression of GLUT-1 in epithelial ovarian carcinoma:Correlation with tumor cell proliferation,angiogenesis,survival and ability to predict optimal cytoreduction[J].Gynecologic Oncology,2011,(01):181-186.
  • 6周锦棠,蔡志明,李宁忱,那彦群.缺氧诱导因子1α和葡萄糖转运因子1蛋白在肾癌和膀胱癌组织表达的临床意义[J].中华医学杂志,2006,86(28):1970-1974. 被引量：9
  • 7Hoskin PJ,Sibtain A,Daley FM. GLUT-1 and CAIX as intrinsic markers of hypoxia in bladder cancer:relationoship with vasculaity and proliferation as predictors of outcomes of ARCON[J].British Journal of Cancer,2003,(10):1290-1297.

二级参考文献16

  • 1Brown JM, Giaccia AJ. The unique physiology of solid tumors:opportunities ( and problems) for cancer therapy. Cancer Res, 199858:1408-1416.
  • 2Zhong H, De Matzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Bes, 1999,59:5830-5835.
  • 3Ebert BL, Firth JD, Ratcliffe PJ. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cisacting sequences. J Biol Chem, 1995,270:29083-29089.
  • 4Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer, 1955,9:539-549.
  • 5Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer,2003,3:721-732.
  • 6Talks KL, Turley H, C, atter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol, 2000,157:411-421.
  • 7Theodoropoulos VE, Lazaris AC, Kastfiotis I, et al. Evaluation of hypoxia-inducible factor l alpha overexpreasion as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma. BJU lilt, 2005,95:425-431.
  • 8Theodoropoulos VE, Lazaris Ach, Sofras F, et al. Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol, 2004,46:200-208.
  • 9Gnarra JR, Tory K, Weng Y, et al.Mutation of the VHL tumour suppressor gene in renal carcinoma. Nat Genet, 1994,7:85-90.
  • 10Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1 alpha in clear cell renal carcinomas. Cancer Res,2001,61:5215-5222.

共引文献8

同被引文献12

引证文献2

二级引证文献14

山东医药
2012年 第23期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部