急性脑梗死患者糖代谢水平与预后的关系

Blood glucose levels on the prognosis of patients with acute cerebral infarction

目的:探讨脑梗死急性期糖代谢水平与预后的关系。方法:102例急性脑梗死患者根据入院次日及7 d后空腹血糖、餐后2 h血糖和糖化血红蛋白水平,分为糖尿病组、应激性血糖升高组和血糖正常组,分析不同血糖水平对急性脑梗死患者病情轻重、梗死灶大小及预后的关系。结果:糖尿病组、应激性血糖升高组病情重,预后差,与血糖正常组比较差异有统计学意义(P<0.01或P<0.05),糖尿病组梗死灶大,与应激性血糖升高组、血糖正常组比较差异有统计学意义(P<0.05)。结论:糖代谢水平可反映急性脑梗死患者病情轻重、梗死灶大小及预后,监测血糖并控制其在正常范围内可改善预后。

Objective： To investigate the relationship between the blood glucose levels and prognosis in patients with acute cerebral infarction. Methods ： The fasting blood glucose （ FBG ） , 2-hour postprandial blood glucose（P2BG） and glycosylated hemoglobin Alc（GHbA1c） were determined respectively at the second day of admission and 7 days after hospital stay in 102 patients with acute cerebral infarction, who were assigned to groups of diabetics, stress-induced hyperglycemia and normoglycemia according to the levels observed, and examined concerning the relationship between blood glucose and disease condition and sizes of infarction on the prognosis. Results ： Patients associated with diabetic history and stress-induced hyperglycemia demonstrated severer condition and poor prognosis compared with those of no rmoglycemia, which was statistically different （ P 〈 0.01, P 〈 0.05 ）. Still, the diabetic group had larger size of infarc- tion and statistical difference as compared with those with stress-induced hyperglycemia and normal blood glucose （ P 〈 0. 05 ）. Conclusion ： The blood glucose level can be index for estimation of the disease condition, size of infarction and prognosis, and further, monitoring of and controlled blood glucose wilhin normal concentration will benefit the patients with acute cerebral infarction from better prognosis.