摘要
目的观察灯盏花素注射液预防缺血性脑卒中术后下肢深静脉血栓(DVT)形成的临床疗效和应用价值。方法将200例缺血性脑卒中术后DVT患者随机分为两组,其中治疗组100例静脉注射灯盏花素,对照组100例皮下注射低分子肝素钠,观察两组临床疗效、临床积分、血栓分型和血管内皮功能指标。结果治疗组在临床疗效和临床积分方面均优于对照组,特别在改善临床积分方面效果更为显著(P<0.01)。血管内皮功能指标方面治疗组tPA水平较对照组增加更显著(P<0.05),ET-1水平、PAI活性、PL活性、AT-Ⅲ水平未见统计学差异(P>0.05)。灯盏花素治疗组未见明显毒副作用,而对照组出现牙龈出血、鼻黏膜出血和注射部位血肿等不良反应。结论灯盏花素注射液预防缺血性脑卒中术后下肢深静脉血栓形成安全有效,具有临床应用价值。
Objective To investigate the curative effect and application value of breviscapine in the prevention of deep venous thrombosis after ischemic stroke surgery. Methods 200 ischemic stroke patients were randomly divided into two groups., breviscapine treatment group and control group administrated with the injection of low molecular heparin sodium, 100 patients in each. The curative effect, clinical integrals, thrombus types and endothelial indexes were measured. Results Breviscapine treatment group was better than control group in the curative effect, clinical integrals and incision drainage amount after the surgery, particularly in clinical integrals (P〈0. 01). The levels of ET-1, PAI, PL and AT-Ⅲ showed no significant difference between treatment group and control group (P〉0. 05). However, tPA level was higher in treatment group than control group (P〈0. 05). No toxic and side effects were observed in treatment group, but gum and nasal bleeding and hematoma of injective site were observed in control group. Conclusion Breviscapine is safe and effective in the prevention of deep venous thrombosis after ischemic stroke surgery.
出处
《西部医学》
2012年第6期1092-1094,共3页
Medical Journal of West China
关键词
灯盏花素
低分子肝素
缺血性脑卒中
下肢深静脉血栓
Breviscapine
Low molecular heparin sodium
Ischemic stroke surgery
Deep venous thrombosis