甲地孕酮联合格拉司琼预防化疗所致消化道反应的疗效观察

Clinical Observation of Megestrol Acetate plus Granisetron in the Preventive Treatment of Gastrointestinal Induced by Chemotherapy

目的观察甲地孕酮联合格拉司琼预防化疗所致消化道反应的疗效及毒副反应。方法将76例接受含顺铂、阿霉素及环磷酰胺联合化疗的恶性肿瘤患者随机分为治疗组和对照组。治疗组止吐方案:甲地孕酮+格拉司琼+甲氧氯普胺;对照组止吐方案:格拉司琼+甲氧氯普胺,2周期后评价疗效。结果Ⅱ度以上急性恶心、呕吐及迟发性恶心呕吐发生率,治疗组分别为5.3%、9.2%及6.6%;对照组分别为23.7%、28.9%及21.1%,2组比较差异均有统计学意义(P均<0.05)。治疗后治疗组生活质量改善明显优于对照组(P<0.05)。2组毒副反应相近,均较轻微,可耐受。结论甲地孕酮联合格拉司琼预防化疗所致恶心呕吐较单用格拉司琼具有更好的预防效果,并可明显改善患者的生活质量。

Objective To observe the effect and toxicities of megestrol acetate plus granisetron in the preventive treatment of gastrointestinal reaction induced by chemotherapy. Methods All the 76 patients treated by cisplatin, adriamycin and cyclophosphamide were devided into the treatment group and the control group randomly. The patients of the treatment group were treated with megestrol acetate ＋ granisetron ＋ metoclopramide, those of the control group were treated with granisetron ＋ metoclopramide, the effect and toxicities were evaluated after 2 cycles of treatment. Results The incidence of grade Ⅱ -Ⅳ acute nausea,acute vomiting and delayed nausea and vomiting in the treatment group were 5.3% ,9.2% and 6.6% ; and those of the control group were 23.7% ,28.9% and 21.1% , the differences between the two groups were statistically significant （ P 〈 0.05 ）. The quality of life after chemotherapy in the treatment group was superior to the control group. The toxicities in two groups were similar and relatively mild. Conclusion Megestrol acetate plus granisetron in preventing nausea and vomiting induced by chemotherapy is superior to granisetron alone, and can improve the quality of life of the patients obviously.