上海市区中老年骨质疏松症患者骨折风险的FRAX^(TM)评估报告

Assessment report on fracture risk in Shanghai senior patients with osteoporosis

目的调查上海市区中老年骨质疏松症患者的骨折风险。方法对纳入的300例病例采用FRAXTM10年骨折风险评估表,调查患者年龄、性别、身高、体质量、脆性骨折史、父母脆性骨折史、口服激素史、类风湿关节炎史、吸烟史、饮酒史,并测定L1-L4和髋部骨密度;分析不同年龄段主要部位脆性骨折风险、髋部脆性骨折风险以及骨折风险与年龄、体质量指数、骨密度的相关性。结果①300例调查者中男女比例为1∶3.6;女性患者腰椎和髋部骨密度均明显低于男性患者(P<0.05),主要部位脆性骨折风险和髋部脆性骨折风险均明显大于男性患者(P<0.05)。②不同年龄段女性主要部位脆性骨折风险和髋部脆性骨折风险不同,主要部位脆性骨折风险以60～69岁年龄段最高(P<0.05),髋部脆性骨折风险以70～79岁年龄段最高(P<0.05)。③主要部位脆性骨折风险与腰椎及髋部骨密度均呈线性负相关(r=-0.443,r=-0.545),与男性患者体质量指数和年龄呈线性负相关(r=-0.349,r=-0.617)。④髋部脆性骨折风险与腰椎骨密度、髋部骨密度及体质量指数呈线性负相关(r=-0.405,r=0.676,r=-0.19),与女性患者年龄呈线性正相关(r=0.213)。结论上海市区中老年骨质疏松症患者中女性骨折风险较高,且主要部位脆性骨折风险以年龄在60-69岁者最高,髋部骨折风险以70-79岁者最高;骨折风险与骨密度成负相关。

Objective To investigate the fracture risk in Shanghai senior palients with osteoporosis. Methods Three hundred eases were investigated by evaluation sheet im：hnting： the age, gender, height, weight, fragility fiaeture history, parents fragility fi＇acture history, hormone history, rheumatoid arthritis history, smuking history and drinking history. The bone density of LI-IA was observed ; the fracture risk at different ages, the fraeture risk of hip and correlation of fracture risk, age, weigbt index and bune density were analysed. Results ① Male and fetnale ratio was 1：3.6 in 300 eases. The lumbar vertebrae density and hip density of frmale were lower than the male （ P 〈 0.05 ）, the fraeture risk at main parts and fraeture risk of hip in female were higher than male （ P 〈 0.05 ）. ②The fracture risk at main paris and fraeture risk of hip in female at dift〉rent ages were different, the fraeture risk at main parts was the highest at 60- 69 years uld （ P 〈 0.05 ） , fracture risk of hip was the highest at 70 - 79 years.＇ oht （ P 〈 0.05）.③ There was negative correlation between fracture risk at main parts aml fraeture risk of hip （ r = - 0. 443, r - 0. 545 ） , and fracture risk at main parts was negative correlated with weight index and age in male （ r = - 0. 349, r = - 0.617 ）. （.4） The frae- lure risk of hip was negative eorrelated with lumbar veriebrae density, hip densily and weight index （ r = - 0. 405, r = 0. 676,r = - 0.19 ）, and it was negaltive cor- related with age of female （ r = 0. 213 ）. Conclusion The fi＇aeture risk in Shanghai female patients with osteoporosis was higher. The main parts of fracture risk is highest at the age of 60 - 69, and the fracture risk of hip is highest at the age of 70 -79. There is negative correlation between fracture risk and hone density.