燃煤型氟暴露相关因素在男性不育中的危险度探讨

Exploring on the risk of coal-burning fluorine exposure related factors in male sterility

[目的]探讨燃煤型氟暴露对男性不育的影响。[方法]对227名病例和对照进行与氟暴露相关的生活居住环境、饮食情况、生育情况等的调查,采用Epidata 3.0软件建立数据库,然后进行非条件Logistic回归分析筛选危险因素。[结果]燃煤型氟病区男性不育的危险因素包括年龄(OR=3.52)、吸烟(OR=1.75)、主食炉火烘干(OR=4.25)及食用前少淘洗(OR=2.19);生育能力低下的危险因素包括年龄(OR=5.64)、主食炉火烘干(OR=4.24)及食用前少淘洗(OR=3.77)、喜欢喝自产烘干茶(OR=3.62);而文化程度(OR=0.37)及主食密闭储存(OR=0.58)则为其保护因素。[结论]煤烟型氟暴露可致男性人群不育的风险升高,主食少用炉火烘干及食用前多淘洗对降低燃煤型氟中毒地区的男性不育风险具有积极的作用。

Objective To explore the effects of coal-burning fluorine exposure in male sterility. Methods Investigated 227 cases and compared group whose related factors including their living environment, diet, bear status, etc. Set up data base by Epidata 3.0 software. Then screened risk factors by non-conditional logistic regression analysis. Results Sterility risk factors included age （OR=3.52）, smoking （OR=1.75）, ingle drying of staple food （OR= 4.25） and less washing before eating （OR=2.19）; low fertility risk factors included age （OR=5.64）, ingle drying of staple food （OR=4.24）, less washing before eating （OR=3.77）, and like drinking home-made oven dry tea （OR=3.62）; while education degree（OR=0.37） and staple food airtight storage （OR=0.58） were its protective factors. Conclusions Coal-burning fluorine exposure increase the risk of male sterility, and less ingle drying of staple food and more washing before eating have positive effects on reducing the risk of male sterility in coal-burning endemic fluorosis areas.