中青年急性脑梗死患者血尿酸与颈动脉斑块及其稳定性的关系

Study on relationship between serum level of uric acid and carotid artery plaque in young and mid aged patients with acute cerebral infarction

目的探讨中青年急性脑梗死(ACI)患者血尿酸(UA)与颈动脉粥样硬化(CAS)斑块及其斑块稳定性的关系。方法对入选85例中青年ACI患者,应用彩色多普勒超声检查,测量颈动脉内中膜厚度(IMT),同时检测患者血UA水平,判断颈动脉斑块的稳定性与血UA的关系。结果中青年ACI合并颈动脉斑块的患者血清UA明显高于无颈动脉斑块患者(P<0.05),且不稳定斑块的患者血清UA显著高于稳定斑块的患者(均为P<0.05)。结论血清UA水平与中青年ACI患者颈动脉粥样硬化的发生及斑块稳定性密切相关。

Objective To study the correlation between serum level of uric acid（UA） and carotid artery plaque in young and mid aged patients with acute cerebral infarction（ACI）.Methods A total of 85 young and mid aged patients with acute cerebral infarction were divided into three different groups,i.e.,normal,stable plaque and unstable plaque groups,based on finding of ultrasound imaging.The serum levels of UA in these patients were detected.Results The serum level of uric acid was higher in patients with different carotid artery plaque groups than that of patients with normal carotid artery group（P 〈 0.05）,and following the elevation of serum level of uric acid,the larger area of carotid artery unstable plaque would be（P 〈 0.05）.Conclusion Serum level of UA is strongly associated with carotid artery plaque in young and mid aged patients with ACI.