冠心病患者胰岛素抵抗与血脂水平的相关性分析

Study on relationship between insulin resistance and blood level of lipids in patients with coronary heart diseases

目的探讨冠心病患者胰岛素抵抗与血脂异常的相关性。方法将收治的46例冠心病患者作为研究组,并随机选取同期门诊体检的健康者46例作为对照组,分别检测两组空腹胰岛素、空腹血糖和血脂水平,计算两组受检者胰岛素释放指数和胰岛素抵抗指数。结果①两组血糖水平无显著差异(P>0.05),研究组胰岛素、胰岛素释放指数和胰岛素抵抗指数较对照组明显升高(P<0.05);②研究组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平较对照组明显升高,高密度脂蛋白胆固醇较对照组明显降低(P<0.05);③研究组胰岛素抵抗指数与甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平呈正相关,与高密度脂蛋白胆固醇水平呈负相关。结论冠心病患者存在胰岛素抵抗,并且胰岛素抵抗与患者血脂水平呈相关性,提示胰岛素抵抗在冠心病发病与发展中起重要的作用。

Objective To study the relationship between insulin resistance and blood level of lipids in patients with coronary heart diseases.Methods Forty six patients with coronary heart diseases were allocated into study group,and 46 healthy persons were randomly selected from out-patient department as control group.Blood levels of fasting glucose,fasting insulin and lipids of subjects in these two groups were examined,and the indexes of insulin resistance and insulin release were calculated.Results ①There was no significant difference in blood level of glucose between these two groups（P 〉 0.05）.The blood level of insulin,insulin release index and insulin resistance index in patients of study group were significantly higher than those of control group（P 〈 0.05）.② The blood levels of triglyceride,total cholesterol and low-density lipoprotein were significantly higher than those of control group,and level of high-density lipoprotein was significantly lower than that of control group（P 〈 0.05）.③ Insulin resistance index and blood levels of triglyceride,total cholesterol and low-density lipoprotein in patients of study group were positively correlated with the severity of disease,and blood level of high density lipoprotein was negatively correlated with the severity of disease.Conclusion There is insulin resistance existed in patients with coronary artery diseases and insulin resistance is correlated with blood level of lipids,thus it suggests that insulin resistance plays an important role in the development of coronary heart diseases.