丙戊酸钠联合氯硝西泮治疗难治性癫痫的疗效观察

Clinical study on efficacy of valproate combined with clonazepam in treatment of refractory epilepsy

目的观察丙戊酸钠联合氯硝西泮治疗难治性癫痫的临床疗效及不良反应。方法 125例难治性癫痫患者随机分为两组,治疗组(n=65)采用丙戊酸钠联合氯硝西泮治疗,对照组(n=60)采用苯妥英钠治疗,两组疗程均为6个月,观察两组治疗总有效率及治疗期间不良反应情况。结果治疗组总有效率(89.2%)明显高于对照组(78.3%)(P<0.05),两组治疗过程中未出现严重不良反应。结论丙戊酸钠联合氯硝西沣治疗难治性癫痫疗效显著,不良反应少,值得临床推广应用。

Objective To study the clinical efficacy and adverse reactions of valproate combined with clonazepam in treatment of refractory epilepsy. Methods One hundred and twenty five patients with refractory epilepsy were randomly divided into two groups. Patients in trial group （n =65） were treated by valproate combined with clonazepam, and patients in control the group （n=60） were only treated with phenytoin. The therapeutic course in both two groups was six months. The total effective rate and adverse reactions were observed and compared. Results The total effective rate of patients in trial group （90.8 % ） was significantly better than that of patients in control group （78.3 % ） （ P 〈 0.05 ）. There was no obvious adverse reaction happened in these two groups during therapeutic course. Conclusion The treatment of valproate combined with clonazepam has good therapeutic effect on refractory epilepsy without any adverse reaction. It is worthy to be recommended for clinical application.