非典型呼吸道感染病原体检测在儿童急性呼吸道感染中的意义

Clinical value of atypical pathogens for children with acute respiratory infection

目的了解非典型呼吸道病原体在儿童急性呼吸道感染中的所占比率,探讨呼吸道病原体联检的临床价值。方法采集656名呼吸道感染小儿的血清,用间接免疫荧光法检测九种非典型病原体:嗜肺军团菌血清I型(LP1)、肺炎支原体(MP)、Q热立克次体(QFR)、肺炎衣原体(CPn)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INFB)和副流感病毒(PLVs)。结果 656例小儿患者中,总的非典型呼吸道病原体感染率为33.23%,其中感染率最高的是MP(12.96%),中等感染率为ADV,RSV,INFA、INFB和PLVs,它们的感染率分别为5.49%,3.35%,3.81%,2.74%和2.90%。感染率最小的病原群体为LP1、QFR和CPn,它们的感染率分别只有0.76%,0.30%和0.91%。结论非典型呼吸道病原体的检测对小儿急性呼吸道感染病原体的确诊有着重要的临床意义。

Objective To understand the infectious rate of atypical pathogens in children with acute respiratory infection and investigate its clinical value. Methods Sera from 656 infectious children were collected, indirect immunofluorescence was applied to detect IgM to Legonella pneumophilal （ LP1 ）, Mycoplasm pneumonia （ MP）, QF - Richettsia （ QFR）, Chlamydia pneumonia（ CPn）, Adenovirus（ ADV）, Respiratory syncytial virus（ RSV）, Influenza A virus（ IN- FA）, Influenza B virus（INFB） and Parainfluenza virus （PLVs）. Results The total positive rate was 33.23 % among 656 children with acute respiratory infection. The positive rate of MP was 12.96%, the highest infectious pathogen; the positive rate of ADV, RSV, INFA, INFB and PLVs were 5.49%, 3.35%, 3.81%, 2.74% and 2.90% respectively, these pathogens were labeled as moderate infectious factors; the pathogens with the lowest positive rate were LP1, QFR and CPn, their infectious rates were 0. 76%, 0. 30% and 0.91% respectively. Conclusions The detection of atypical pathogens in children with acute respiratory infection is conducive to diagnosis.