舒血宁治疗肺心病急性加重期患者30例疗效观察

Clinical observation of Shuxuening in treatment of patients with pulmonary heart diseases of acute attack

目的探讨肺源性心脏病(PHD)急性加重期患者凝血纤溶系统的变化以及银杏叶提取物干预治疗的效果。方法 60例肺心病患者随机分为常规组和联合治疗组,每组各30例。两组常规治疗相同,治疗组每日再另加用舒血宁注射液20ml静滴,连用14d。并分别检测血浆凝血四项等指标的变化。结果临床疗效突出,住院时间缩短一周以上;治疗组纤维蛋白原(FBG)显著低于常规组(P<0.05)。治疗组和常规组治疗前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)比较无统计学差异。结论肺心病患者存在凝血纤溶系统失衡状态,舒血宁可改善血液高凝状态,并能减少住院天数。

Objective To investigate the function of coagulative and fibrinolytic system of patients with pulmonary heart diseases （PHD） of acute attack, and evaluate the effects of ginkgo biloba extract （GBE） on above targets. Methods Sixty patients with PHD were randomly divided into two groups ：conventional treatment （CT） group and GBE treatment （GBE） group, each consisting of 30 cases, all PHD patients were given conventional treatment, while for the patients in GBE group 20ml GBE were given through intravenous drip everyday in addition for 14 days. The levels of plasma 4 indexes of coagulation （PT,APTT,TT, FBG）. Results The effects of GBE group were good. Shorten hospitalization time for a week. The level of FBG [ （4. 18 ± 0.98 ） g/L ] was significantly lower than those in the CT group [ （4. 89 ± 1.03 ） g/L, P 〈 0.05 ]. PT, APTT,TT were not significantly different in two groups. Conclusions Abnormality of coagulative and fibrinolytic system exists in PHD patients. GBE can improve the disorders and shorten patients＇hospitalization days.