帕利哌酮对精神分裂症患者社会功能影响的随访研究

The One Year Follow-up Study on Effect of Paliperidone on Social Function of Patients with Schizophrenia

目的比较帕利哌酮与利培酮长期服用对精神分裂症患者社会功能的影响。方法 160例病程小于5年的精神分裂症患者随机分为帕利哌酮组与利培酮组各80例进行为期1年的随访,在治疗前、治疗12月末进行个人和社会功能量表(PSP)评定。结果帕利哌酮组73例完成研究,利培酮组75例完成研究。与治疗前相比,两组1年后PSP评分均有很大提高,帕利哌酮组较利培酮组更明显(t=3.51,P<0.001);帕利哌酮组在社会中有用的活动(χ2=11.88,P<0.01)、个人和社会关系(χ2=9.08,P<0.01)2个维度较利培酮组改善更明显。结论长期服用帕利哌酮能不断提高精神分裂症患者社会功能,帕利哌酮对社会功能的改善优于利培酮。

Objective To compare the effect of paliperidone and risperidone on social function of patients with schizophrenia after a long term.Methods A total of 160 cases of patients with schizophrenia whose courses of disease were less than 5 years were divided into paliperidone group and risperidone group with 80 cases in each group.All the cases were followed up in one year and the personal and social function were assessed before the treatment and at the end of December by PSP.Results A total of 73 patients in paliperidone group completed the study,75 patients in risperidone group completed the study.Compared with the situation before treatment,PSP score had greatly improved in both groups after one year,the paliperidone group was more significant（t=3.51,P0.001）;Compared to the risperidone group,the paliperidone group was improved significantly in useful activities in society（χ2=11.88,P0.01）,personal and social relationship（χ2=9.08,P0.01）.Conclusion The long-term use of paliperidone can continuously improve the social function of patients with schizophrenia.Paliperidone is better than risperidone in improvement of social function.