摘要
目的确定本中心不同周龄SD大鼠脏器重量与脏器系数的正常参考值范围,为药物安全性评价与研究提供重要参考数据。方法以本中心近7年开展的SD大鼠长期毒性实验中空白对照组动物为数据来源,分为8~12、12~24及24~36周龄3个年龄段,每年龄段包括雌性、雄性大鼠各200只,分别统计各年龄段雌性、雄性动物的脑、心脏、肺脏、肝脏、脾脏、肾脏、肾上腺、胸腺、睾丸、附睾、卵巢与子宫等脏器重量与脏器系数,以95%可信区间作为正常参考值范围。结果与结论本中心8~12、12~24及24~36不同周龄SD大鼠脑、心脏、肺脏、肝脏、脾脏、肾脏、肾上腺、胸腺、睾丸、附睾、卵巢与子宫等脏器重量及脏器系数的正常参考值范围与其他实验室报道的结果可比性良好。
Objective To establish the normal reference values of the mass and coefficients of main organs of SD rats in order to provide important background data for National Beijing Center for Drug Safety Evaluation and Research ( NBCDS- ER). Method This study involved 1200 SD rats from the control groups of the repeated dosing toxicity tests conducted at NBCDSER in the past seven years, aged 8 to 12, 12 to 24 and 24 to 36 weeks, with males and females in half. The mass and coefficients of the brain, heart, lung, liver, spleen, kidney, adrenal gland, thymus, testis, epididymis, ovary and uterus were statistically analyzed. The normal reference values were set at x± 1.96SD. Results and Conclusion The nor- mal reference values of organ masses and coefficients in SD rats in NBCDSER are comparable to the data from other labora- tories in China.
出处
《军事医学》
CAS
CSCD
北大核心
2012年第5期351-353,共3页
Military Medical Sciences
基金
国家科技重大专项资助项目(2008ZX09305-003
2010ZXJ0900X-005)