探讨慢性乙型肝炎患者血清肝纤4项指标与血小板的相关关系

目的探讨慢性乙型肝炎患者血清肝纤维化4项指标与血小板数量(PLT)的相关性。方法对慢性乙型肝炎患者PLT测定的同时,采用r-放免计数仪测定血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型胶原(PCⅢ)、Ⅳ型胶原(CⅣ)4个肝纤维化指标,然后应用SPSS 13.0统计分析软件对所得数据进行相关性分析。结果在慢性乙型肝炎中,随着肝炎严重程度的增大,HA的值明显增大(P<0.05),LN、PCⅢ、CⅣ变化不明显;随着PLT值的增大,肝纤维化4项指标中除了LN,HA、PCⅢ、CⅣ3项的血清水平均显著下降(P<0.05)。结论 HA与PLT的相关性最好,是反映肝纤维化最好的指标之一,综合考虑HA等相关肝纤及PLT是诊断肝纤维化有效的血清学方法。

Objective To investigate the relationship between the liver fibrosis indexes and PLT in patients with chronic hepatitis B disease.Methods PLT were measured,mean-while,the values of the four liver fibrosis indexes,including HA,LN,PC Ⅲ and CⅣ were detected by the method of R-RIA counter.Then the data were correlatively analyzed with the statistics software SPSS 13.0.Results As the hepatitis B becoming more serious among each group,the values of HA were increased significantly(P < 0.05),but the values of LN,PCIII,and CⅣ were not changed significantly.With the increasing value of PLT,the values of HA,PC Ⅲ,and CⅣ were all decreased significantly(P < 0.05) except LN.Conclusion The value of HA has the best correlation with PLT,and it is one of the best liver fibrosis indexes.Combined considering the values of the liver fibrosis indexes and PLT is a good way for predicting the degrees of liver fibrosis.