慢性肾脏病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用

Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine

肾组织的炎症反应及其相关的组织损伤(如肾小球硬化和肾间质纤维化)是导致慢性肾脏病(chronic kidneydisease,CKD)进展至终末期肾病的重要因素。其中,p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路能够调控多种核转录因子的表达和生物活性,还可以影响下游炎症介质的合成,并参与炎症细胞的活化,在肾脏疾病炎症损伤中发挥着重要的作用。某些单味中药及其提取物(如大黄素、黄连素)以及一些中药复方(如益肾活血汤)可以通过调节p38MAPK信号通路而影响肾组织内炎症反应,从而,减轻肾小球、肾间质炎症损伤。

The inflammatory reaction of renal tissues and its relevant tissue damages （ such as glomerulosclerosis and renal in- terstitial fibrosis） ale important factors for the development of chronic kidney diseases （CKD） to end-state renal diseases. Of them, p38 mitogen-activated protein kinase （MAPK） signaling pathway plays an important role in regulating expression and bioaetivity of mul- tiple nuclear transcription factors, impacting synthesis of downstream inflammatory mediators and activating inflammatory cells. Some monomer traditional Chinese medicines and their extracts （ such as emodin and berberine） and some traditional Chinese medicine com- pound prescriptions （such as Yishen Huoxue decoction） can affect inflammatory reaction of renal tissues by regulating p38MAPK signa- ling pathway, thas improving reduce glomerulus and renal interstitial inflammatory iniury.