无梗五加果酚酸类化学成分的研究

Studies on phenolic acid constituents of Acanthopanax sessiliflorus fruits

目的对五加科五加属植物无梗五加果的化学成分进行研究。方法采用硅胶柱色谱法、Sephadex LH-20柱色谱法、ODS柱色谱法以及制备液相色谱法对无梗五加果的化学成分进行分离,根据化合物的理化性质及波谱数据鉴定其结构。结果分离得到8个已知的酚酸类化合物,分别为对羟基苯乙醇(tyrosol,1)、对羟基苯丙酸(p-hydrocoumaric acid,2)、原儿茶醛(protocatechuic aldehyde,3)、咖啡酸(caffeic acid,4)、4-(3,4-二羟基苯基)-2-丁酮[4-(3,4-dihydroxyphenyl)-2-butanone,5]、没食子酸(gallic acid,6)、对羟基苯甲酸(4-hydroxy-benzoic acid,7)、邻苯二酚(pyrocatechol8,)。结论化合物5为首次从五加科植物中分离得到,化合物2为首次从五加属植物中分离得到,化合物17、、8为从该植物中首次分离得到。

To study the chemical constituents of the fruits from Acanthopanax sessiliflorus, the seperation was carried out on the column chromatography of silica gel, Sephadex LH-20, ODS and preparative liquid chromatography. Their structures were elucidated on basis of physicochemical properties and spectral data. Eight phenolic acid compounds were isolated and identified as tyrosol （1）,p-hydrocoumaric acid （2）, protocatechuic aldehyde （ 3 ）, caffeic acid （ 4 ）, 4- （ 3,4-dihydroxyphenyl ） -2-butanone （ 5 ）, gallic acid （ 6 ）, 4-hydroxy- benzoic acid（ 7 ）, pyrocatechol （8）. Compound 5 was isolated from the family of Araliaceae for the first time. Compound 2 was isolated from Acanthopanax genus for the first time, and compounds 1,7,8 were iso- lated from Acanthopanax sessilitlorus for the first time.