摘要
目的对五加科五加属植物无梗五加果的化学成分进行研究。方法采用硅胶柱色谱法、Sephadex LH-20柱色谱法、ODS柱色谱法以及制备液相色谱法对无梗五加果的化学成分进行分离,根据化合物的理化性质及波谱数据鉴定其结构。结果分离得到8个已知的酚酸类化合物,分别为对羟基苯乙醇(tyrosol,1)、对羟基苯丙酸(p-hydrocoumaric acid,2)、原儿茶醛(protocatechuic aldehyde,3)、咖啡酸(caffeic acid,4)、4-(3,4-二羟基苯基)-2-丁酮[4-(3,4-dihydroxyphenyl)-2-butanone,5]、没食子酸(gallic acid,6)、对羟基苯甲酸(4-hydroxy-benzoic acid,7)、邻苯二酚(pyrocatechol8,)。结论化合物5为首次从五加科植物中分离得到,化合物2为首次从五加属植物中分离得到,化合物17、、8为从该植物中首次分离得到。
To study the chemical constituents of the fruits from Acanthopanax sessiliflorus, the seperation was carried out on the column chromatography of silica gel, Sephadex LH-20, ODS and preparative liquid chromatography. Their structures were elucidated on basis of physicochemical properties and spectral data. Eight phenolic acid compounds were isolated and identified as tyrosol (1),p-hydrocoumaric acid (2), protocatechuic aldehyde ( 3 ), caffeic acid ( 4 ), 4- ( 3,4-dihydroxyphenyl ) -2-butanone ( 5 ), gallic acid ( 6 ), 4-hydroxy- benzoic acid( 7 ), pyrocatechol (8). Compound 5 was isolated from the family of Araliaceae for the first time. Compound 2 was isolated from Acanthopanax genus for the first time, and compounds 1,7,8 were iso- lated from Acanthopanax sessilitlorus for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2012年第3期223-226,共4页
Chinese Journal of Medicinal Chemistry
基金
黑龙江省卫生厅基金资助项目(2010-198)
关键词
无梗五加果
化学成分
酚酸类
结构鉴定
Acanthopanax sessiliflorus fruits
chemical constituent
phenolic acid
structural identification