N-末端脑钠肽检测对急性呼吸困难的鉴别诊断价值

The Value of N-terminal Brain Natriuretic Peptide in the Differential Diagnosis of Acute Dyspnea

目的探讨血浆N-末端脑钠肽水平测定在急诊呼吸困难鉴别诊断及病情评估中的价值。方法收集2008-08～2011-09间,来本院就诊的急性呼吸困难患者118例的病历资料,分成心源性呼吸困难组和非心源性呼吸困难组,并进行整理、统计和分析。结果因充血性心力衰竭(CHF)引起的急性呼吸困难患者N-末端脑钠肽浓度明显高于非CHF组患者(P<0.01);CHF组N-末端脑钠肽浓度在心功能不同级别间差异有统计学意义,与左室射血分数呈负相关。结论血浆N-末端脑钠肽对急性呼吸困难的鉴别诊断有重要意义。

Objective To investigate the value of the changes of plasma N-terminal pro-brain natriuretic peptide levels in the diagnosis and pathogenetic assessment of acute dyspnea. Methods From 2008-08 to 2011-09 in our hospital,118 cases of acute dyspnea patients were divided into cardiac dyspnea group and non-cardiac dyspnea group,and the data were collected,statistics and analysis. Results The N-terminal pro-brain natriuretic peptide concentration in the patients with Congestive heart failure（CHF） was significantly higher than the non-CHF patients（P0.01）;N-terminal pro-brain natriuretic peptide differences among the different levels of heart function and has statistically significant.It was negatively correlated with left ventricular ejection fraction. Conclusion Plasma N-terminal pro-brain natriuretic peptide has significance in the differential diagnosis of acute dyspnea.