A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols

A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols

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摘要 This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis. This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.

作者王文伶龙玉华邹志富杨定乔

机构地区 School of Chemistry and Environment

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第5期1092-1096,共5页 中国化学（英文版）

关键词（R）-1 1＇-bi-2-naphthols derivatives Suzuki cross coupling reaction chiral auxiliary SYNTHESIS （R）-1,1＇-bi-2-naphthols derivatives, Suzuki cross coupling reaction, chiral auxiliary, synthesis

分类号 O626.11 [理学—有机化学] O753.2 [理学—晶体学]

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Chinese Journal of Chemistry

2012年第5期

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A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols

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