小鼠对大黄致泻作用的昼夜节律

Circadian Rhythms of Mice to the Catharsis of Radix et Rhizoma Rhei

健康或病理模型小鼠对大黄致泻作用反应都有明显的昼夜节律,均为晚间给药强于日间给药。但也有不同之处,甲亢模型小鼠使这一节律趋于明显,变动幅度高于健康小鼠,对大黄剂量变化的反应较不敏感,甲低模型小鼠则与之相反。

Circadian rhythms have been observed obviously for both normal and pathological mice when Radix et Rhizoma Rhei is given. As a rule, the catharsis becomes stronger when Radix et Rhizoma Rhei is given at night than during the day. The rhythms vary with different pathological models. Compared with the normal mice, the circadian rhythms tend to be clearer for those mice excited by thyroidization. However, thyroidization makes the mice less sensitive to the dosage change of Radix et Rhizoma Rhei, while the mice weakened by tabazole administration show the reverse reaction.