丹参素对兔肢体缺血/再灌注损伤的保护作用

The Protection of Salvia Miltiorrhia on Rabbit Skeletal Muscle lschemia and Reperfusion Injury

实验制作了兔后肢缺血模型,观察肢体缺血/再灌注损伤后,应用丹参素对骨胳肌的保护作用。结果表明,肢体缺血5小时,丹参组反映肌细胞损伤的细胞内酶(CPK、GOT 和 LDH)较对照组明显下降(P<0.05),自由基清除酶系统超氧化物歧化酶(SOD)的活性显著升高(P<0.01),自由基终末代谢产物丙二醛(MDA)明显降低(P<0.05)。指出丹参素有较强的抗氧化作用,能减轻肢体缺血/再灌注损伤后骨胳肌的损伤。

A rabbit right hindlimb ischemic model was utilized to investigate the protection of salvia miltiorrhia on skeletal muscle ischemia and reperfusion injury.The changes of in- tracellular enzymes(CPK,LDH,COT)were used as indexes of cellular damage.The results showed the plasms levels of CPK,LDH,COT,MDA(an oxygen free radical product)of salvia miltiorrhia group were significantly lower than control group(p<0.05),and superox- ide dismutase(SOD)was signieantly higher than control group(P<0.01).It Suggested that salvia miltiorrhia possessed stronger antioxidation,and may decrease skeletal muscle ischemia and reperfusion injury.