全程IMRT在宫颈癌根治性放疗中的临床研究

Clinical study of intensity modulated radiation therapy in radical radiotherapy of cervical carcinoma

目的探讨全程IMRT(intensity modulated radiation therapy,调强适形放射治疗)在宫颈癌根治性放疗中的疗效。方法对70例ⅡB～ⅢB期宫颈癌患者进行研究,研究组35例行IMRT治疗,对照组35例行常规体外全盆照射。对比两组的肿瘤消退情况以及并发症发生率。结果 IMRT组治愈率及远期控制率高于对照组,并发症发生率低于对照组,两组比较,差异有统计学意义(P<0.05)。结论 IMRT在宫颈癌根治性放疗中较常规体外照射具有明显优势,值得临床推广。

Objective To evaluate the clinical effect of intensity modulated radiation therapy （IMRT） in radical radiotherapy of cervical carcinoma. Methods Seventy patients in stage Ⅱ B-Ⅲ B with cervical carcinoma were studied. Thirty five pa- tients were treated by IMRT, another 35 patients were treated by whole pelvic radiotherapy （WPRT）. The short-term effect and complication incidence of two groups were compared. Results The cure rate and the rate of forward control of IMRT group were higher than that of control group, complication incidence was lower than that of control group. There was statis- tical significant between the two groups （P 〈 0.05）. Conclusion Compared with the conventional radiotherapy, IMRT has an apparent advantage in the treatment of cervical carcinoma. It is worthy of applying in clinic.