贝那普利联合前列地尔治疗糖尿病肾病的临床分析

Clinical analysis of benazepril combined with alprostadil in the treatment of diabetic nephropathy

目的观察贝那普利联合前列地尔治疗糖尿病肾病的临床疗效。方法将94例糖尿病肾病患者按随机数字表法分为两组，每组47例，观察组采用贝那普利联合前列地尔治疗，对照组仅采用贝那普利治疗，对比观察治疗前后两组的临床疗效及24h尿微量白蛋白、血尿素氮和血肌酐水平的变化。结果观察组总有效率为80．9％（38／47），明显高于对照组的68．1％（32/47），差异有统计学意义（P〈0．05）。两组治疗前24h尿微量白蛋白、血尿素氮和血肌酐水平比较差异无统计学意义（P〉0．05）；观察组治疗后24h尿微量白蛋白、血尿素氮和血肌酐水平分别为（212．15±25．59）mg、（7．52±1．81）mmol／L和（105．62±8．51）μmol／L，对照组分别为（332．46±38．71）mg（9．06±2．43）mmol／L和（122．29±11．98）μmol／L，均较治疗前有所改善，但观察组明显低于同期对照组，差异有统计学意义（P〈0．05）。结论贝那普利联合前列地尔对糖尿病肾病进行治疗，能够明显提高疗效，改善肾功能，值得临床推广应用。

Objective To observe the clinical effect of benazepril combined with alprostadil in the treatment of diabetic nephropathy. Methods Ninety-four cases with diabetic nephropathy were divided by random digits table method into two groups with 47 cases in each： observation group （treated with benazepril combined with alprostadil） and control group （treated with benazepril）. The clinical effect,24 h urinary microalbumin,serum urea nitrogen and serum creatinine of the two groups were observed and compared. Results The total effective rate of observation group was 80.9% （38/47）, and significantly higher than that in control group [ 68.1% （32/47） ] （P 〈 0.05 ）. The levels of 24 h urinary microalbumin, serum urea nitrogen and serum creatinine of the two groups before treatment had no significant difference （P 〉 0.05 ）. The levels of 24 h urinary microalbumin, serum urea nitrogen and serum creatinine in observation group after treatment were （212.15 ± 25.59） mg, （7.52 ± 1.81 ） mmol/L and （ 105.62 ± 8.51 ） μ mol/L,while the levels in control group were （332.46 ± 38.71 ） mg, （9.06 ± 2.43） mmol/L and （122.29 ± 11.98） μ mol/L. The levels all improved after treatment compared with those before treatment,and the levels of observation group were obviously lower than those of control group respectively （P 〈 0.05 ）. Conclusions Benazepril combined with alprostadil in the treatment of diabetic nephropathy can improve the clinical effect significantly as well as the kidney function. Therefore, it deserves the application in clinic.