摘要
目的探讨骨桥蛋白OPN和粘附蛋白CD44v6在肺小细胞癌和肺鳞状细胞癌进展中所起的作用及其对患者预后的影响。方法应用免疫组织化学法检测134例肺癌组织标本中OPN和CD44v6的表达情况,比较分析肺小细胞癌患者和肺鳞状细胞癌患者的3年生存率。结果 OPN和CD44v6在肺小细胞癌中的表达均明显低于在肺鳞状细胞癌中的表达,差异有统计学意义(P<0.01);在肺鳞状细胞癌中,OPN和CD44v6的表达呈正相关(r=0.395,P<0.01);在肺鳞状细胞癌中仅CD44v6的表达差异有统计学意义(P<0.05)。两种肺癌患者3年生存率差异有统计学意义(P<0.05)。结论提示CD44v6可作为判断肺鳞状细胞癌预后的独立指标,而OPN不可作为其预后的独立指标,但二者可以联合作为判断肺鳞状细胞癌预后的参考指标。
Objective To study the expression of OPN and CD44v6 in lung small cell cancer （SCLC） and lung squamous cell cancer （ SCC ） and their inner relationships, to discuss their function during the progress of lung cancer and the influence on the patients. Methods The S-P immunhistochemical method was used to detect the expression of OPN and CD44v6 in SCLC and SCC. Three-year survival rates of SCLC and SCC were compared. Results The expression of OPN and CD44v6 in SCLC was significantly lower than that in SCC. （P 〈 0. 05 ）. Positive correlation was found in the expression of OPN and CD44v6 in SCC （r = 0. 395, P 〈 0. 01 ）. The significant difference was found only in the expression of CIM4v6 in SCC （P 〈 0. 05 ）. Three-year survival rates of SCLC and SCC were significantly different （P 〈 0. 05 ）. Conclusion CIM4v6 can act as independent indicator for judging the prognosis of SCC, while OPN is not independent predictor of prognosis, but they can be combined as a reference to judge the prognosis of SCC.
出处
《中国实用医药》
2012年第13期40-41,共2页
China Practical Medicine
