不稳定性心绞痛患者调脂干预对C反应蛋白的影响被引量：2

Effect of atorvastatin on high sensitive C-reactive protein in patients with unstable angina

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摘要目的探讨阿托伐他汀对不稳定性心绞痛(UA)患者血浆高敏C-反应蛋白(hs-CRP)的影响。方法测定60例不稳定性心绞痛患者在常规治疗基础上口服阿托伐他汀(商品名立普妥)20mg,治疗12个月前后血浆hs-CRP。结果 60例不稳定性心绞痛患者经阿托伐他汀治疗12个月后血浆hs-CRP显著下降(P<0.01)。结论阿托伐他汀对不稳定性心绞痛患者减少炎症反应起着重要的作用。 Objective To observe the influence of atorvastatin on serum high sensitive C-reactive pro- tein （hs-CRP） levels in patients with unstable angina. Methods Sixty subjects with arteriosclerosis plaque of coronary artery were given atorvastatin 20 mg qd for 12 months. The serum levels of hs-CRP were detected before and 12 months after treatment in all patients with helical computerized tomography. Results After 12 months administration of atorvastatin, the serum levels of hs-CRP was reduced （P 〈 0. 01 ）. Condusion Atorvastatin decreased inflammatory reaction in patients with unstable angina,which may improve stabiliation of the plaque in coronary artery.

作者廖志坚林泽鹏陈玲

机构地区深圳市孙逸仙心血管医院药剂科深圳市孙逸仙心血管医院门急诊深圳市人民医院二门诊部

出处《中国实用医药》 2012年第13期46-47,共2页 China Practical Medicine

关键词冠心病脂类和降脂药高敏C-反应蛋白 Coronary artery disease Lipids and antilipiemic agents C-reactive protein

分类号 R541.4 [医药卫生—心血管疾病]

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参考文献5

1Dupuis J,Tardif JC,Cernacek P.Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes.The RECIFL trial.Circulation,1999,999(32):3227-3233.
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5罗助荣,盖晓波.不稳定性心绞痛患者调脂干预对颈动脉粥样硬化及C反应蛋白的影响[J].中华心血管病杂志,2004,32(11):977-980. 被引量：40

二级参考文献3

1Dupuis J,Tardif JC,Cernacek P, et al. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes.The RECIFL trial.Circulation,1999,99:3227-3233.
2Waters DD,Azar RR. Should intensive cholesterol lowering play a role in mangement of acute coronary syndromes? Am J Cardiol, 2000,86[Suppl]:35J-43J.
3Pearson TA,Mensah GA,Alexander RW, et al. Markers of inflammation and cardiovascular disease,application to clinical and public health practice:a statement for healthcare professionals from the centers for disease control and prevention and the American H