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运动结合雌激素疗法对绝经早期妇女骨密度的影响 被引量:1

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摘要 目的:观察运动干预结合雌激素补充对绝经早期妇女骨密度的影响。方法:将120例绝经早期妇女随机分为综合组、雌激素组和对照组,综合组每日口服利维爱+钙尔奇D,并进行有氧运动训练(3次/周,1 h/次);雌激素组每日口服利维爱+钙尔奇D,对照组每日口服钙尔奇D。于治疗前、治疗12个月后分别测定第2~4腰椎(L2~4)骨密度(BMD)、血清骨钙素(BGP)、尿吡啶啉(U-Pyd/Cr),以及全身疼痛改善情况和子宫内膜变化情况。结果:治疗12个月后综合组和雌激素组的腰椎总BMD分别较治疗前增加了21.04%(P<0.05)和12.98%(P<0.05),血清BGP分别升高40.59%(P<0.05)和34.25%(P<0.05),U-Pyd/Cr分别下降32.28%(P<0.05)和21.71%(P<0.05),两组比较差异均有统计学意义(P<0.05)。两治疗组各项指标较对照组均有显著变化(P<0.05)。综合组与雌激素组疼痛改善率较对照组显著(P<0.05)。3组子宫内膜治疗前后无明显变化。结论:运动干预结合雌激素补充能有效提高绝经早期妇女骨密度。
作者 何慧 蒋玲珍
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2012年第5期703-705,共3页 Journal of Nanjing Medical University(Natural Sciences)
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