美洲大蠊对免疫性肝纤维化大鼠肝功能的影响

Effect of Periplaneta americana on Liver Function of Rats with Immune Hepatic Fibrosis

[目的]探讨美洲大蠊对免疫性肝纤维化大鼠肝功能的影响。[方法]采用腹腔注射猪血清法诱导大鼠免疫性肝纤维化模型,在造模的同时分别用不同剂量的受试药物(美洲大蠊总提取物和美蠊氨)干预,以秋水仙碱为阳性对照药,分别于试验第4周和第12周结束时取血检测血清中ALT(谷丙转氨酶)、AST(谷草转氨酶)和TBIL(总胆红素)的含量,并在第12周结束时处死大鼠,取肝脏称重并计算肝脏指数。[结果]试验4周后,美洲大蠊总提取物能明显降低大鼠血清中ALT、AST、TBIL的含量。试验12周后,美蠊氨能明显降低大鼠血清中ALT、AST、TBIL的含量,但此时美洲大蠊总提取物对3个指标的影响不大。[结论]美洲大蠊对免疫性肝纤维化具有一定的防治作用,能明显改善肝功能。

[ Objective ] To study the effect of Periplaneta americana on liver function of rats with immune hepatic fibrosis. [ Method ] The im- mune hepatic fibrosis model was induced by porcine serum, different dosages of drugs （ the total extracts from Periplaneta americana and Meili- anah） were administered to the rats, colchicine was took for the positive drug. After 4 weeks and 12 weeks, the alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and total bilirubin （TBIL） in the serum of the rats were detected and the hepatic index after 12 weeks was calculated. [ Result] After 4 weeks, the serum levels of ALT, AST and TBIL was decreased by the total extracts from Periplaneta americana; after 12 weeks, the serum levels of ALT, AST and TBIL was decreased by Meilianan, but hardly influenced by the total extracts from Periplaneta americana. [ Conclusion] Periplaneta americana can prevent the immune liver fibrosis to a certain extent and improve the liver function obviously.