乙型肝炎病毒基因型与抗病毒药物疗效关系的研究进展

Review of recent research progress in correlating HBV genotypes with efficacy of antiviral treatments

乙型肝炎在全球发病率高,严重危害人类健康。随着HBV基因型研究的深入,大量研究显示HBV基因型与临床疾病谱密切相关。目前抗病毒治疗是慢性乙型肝炎治疗的最主要措施,越来越多的学者对HBV基因型与抗病毒药物疗效的关系进行了研究,本文就目前国内外关于HBV基因型与抗病毒疗效关系的研究进展作一综述。

Hepatitis B is one of the most prevalent infectious diseases worldwide.Moreover,chronic hepatitis B virus（HBV） infection is strongly associated with subsequent development of life-threatening hepatic diseases,such as heptocellular carcinoma,decompensated cirrhosis,and advanced fibrosis.Extensive studies of the various HBV genotypes have uncovered a close correlated with clinical factors,which may help to design and implement effective therapeutic strategies for treating infections with the different genotypes.Since antivirus therapy remains the main treatment for hepatitis B,research studies have focused on determining the relations between the various HBV genotypes and efficacy of the currently available antiviral drugs.In this review,we systematically discuss the recent findings from the literature on HBV genotype correlations with efficacy of antivirus treatment.