CCR7在甲状腺乳头状微小癌中的表达及临床意义

Expression and Clinical Significance of The Chemokine Receptor CCR7 in Thyroid Papillary Microcarcinoma

目的探讨CCR7在甲状腺乳头状微小癌中表达情况及其与甲状腺乳头状微小癌临床病理特征的关系。方法采用免疫组织化学S-P法检测31例甲状腺乳头状微小癌,34例直径>1 cm的甲状腺乳头状癌、34例结节性甲状腺肿以及12例甲状腺乳头状微小癌对侧正常甲状腺组织中CCR7的表达情况。结果 CCR7在甲状腺乳头状微小癌及直径>1 cm甲状腺乳头状癌中的表达阳性率均为100%,其差异无统计学意义(P>0.05),而在结节性甲状腺肿和正常甲状腺组织中CCR7的表达阳性率分别为64.7%和33.3%,与甲状腺乳头状微小癌相比差异有统计学意义(P<0.05)。CCR7的表达与患者性别、年龄、侵犯甲状腺被膜及淋巴结转移均无关(P>0.05)。结论 CCR7的表达在甲状腺乳头状微小癌和直径>1 cm甲状腺乳头状癌中均呈高表达,两者可能具有相同的生物学特性,两者均易发生颈淋巴结转移,均需要进行颈淋巴结(中央区)清扫。

Objective To explore the expression of chemokine receptor CCR7 in thyroid papillary microcarcinoma tissues and the relationship with clinicopathological features.Methods The CCR7 expressions in 31 cases of thyroid papillary microcarcinoma,34 cases of thyroid papillary carcinoma which diameter〉1 cm,34 cases of nodular goiter,and 12 cases of thyroid papillary microcarcinoma contralateral normal thyroid tissues were detected by using immunohistochemistry S-P method.Results The expression positive rates of CCR7 in thyroid papillary microcarcinoma and papillary thyroid carcinoma which diameter〉 1 cm were both 100%,the difference had not statistically significant （P〉0.05）.In nodular goiter and normal thyroid tissues,the expression positive rate of CCR7 was 64.7% and 33.3%,respectively,and compared with thyroid papillary microcarcinoma,the difference had statistically significant（P〈0.05）.There were not relations between the expression of CCR7 and patient’s gender,age,capsule invasion,and lymph node metastasis（P〉0.05）.Conclusions The CCR7 in thyroid papillary microcarcinoma and thyroid papillary carcinoma which diameter〉 1 cm are both high expressions,and have the same bionomics,both prone to cervical lymph node metastasis,and the radical neck dissection（central area） are both need to take.