摘要
The oxidant iodosobenzene diacetate was combined with the cheap,environment-friendly FeCl3 as a chloride source to produce an efficient chlorinating agent for α-chlorination of ketene dithioacetals through direct C(sp2)-H chlorination.Furthermore,the synthetic utility of α-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate,leading to the synthesis of pyrazoles,in which a 1,2-sulfur migration was involved.
The oxidant iodosobenzene diacetate was combined with the cheap, environment-friendly FeC13 as a chloride source to produce an efficient chlorinating agent for a-chlorination of ketene dithioacetals through direct C（sp2）-H chlorination. Furthermore, the synthetic utility of a-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate, lead- ing to the synthesis of pyrazoles, in which a 1,2-sulfur migration was involved.
基金
supported by the National Natural Science Foundation of China (20902010 and 21172029)
the Fundamental Research Funds for the Central Universities (10JCXK005)
