期刊文献+

蛛网膜下隙出血对皮质神经元损害的实验研究

Damage of cortical neurons after subarachnoid hemorrhage in rabbits
下载PDF
导出
摘要 采用经枕大池注射自体血方法制备蛛网膜下隙出血兔模型,光学显微镜和电子显微镜下观察神经元凋亡并计算凋亡指数。组织病理学观察神经元呈现延迟性损伤,胞体固缩,胞质及胞核深染,核质不均匀,胞核内染色质部分凝聚;甚至胞核溶解,线粒体肿胀、嵴消失。与空白对照组相比,蛛网膜下隙出血组动物细胞凋亡指数明显升高,且组间差异具有统计学意义(均P<0.05)。提示细胞凋亡在蛛网膜下隙出血后的迟发性神经元死亡过程中起重要作用。 Fresh autologous blood was injected into the cisterna magna to establish the model of spontaneous subarachnoid hemorrhage (SSAH) in the rabbit groups. The neuron apoptosis was observed by optical microscope and eletron microscope, and determination in apoptoic index. Observation by histopathology, neurons show tardive detriment, as cell body pyknosis, cytoplasm and nucleus hyperchromasis, karyoplasms uneven, fraction intranuclear caryotin agglomeration; even caryolysis, bioblast engorgement, crista resorbed. Contrast to blank groups, apoptotic index increased obviously in SAH groups, and statistical significant difference was seen among groups (all P 〈 0.05). Apoptosis plays an important role in delayed neuronal death after subarachnoid hemorrhage.
出处 《中国现代神经疾病杂志》 CAS 2012年第3期337-341,共5页 Chinese Journal of Contemporary Neurology and Neurosurgery
关键词 蛛网膜下腔出血 细胞凋亡 神经元 疾病模型 动物 Subarachnoid hemorrhage Apoptosis Neurons Disease models, animal
  • 相关文献

参考文献8

  • 1Robinson SR, Dang TN, Dringen R, et al. Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke. Redox Rep, 2009, 14:228-235.
  • 2孟伟,贾军,毛宏杰.中脑周围非动脉瘤性蛛网膜下隙出血临床分析[J].中国现代神经疾病杂志,2010,10(3):390-391. 被引量:1
  • 3Endo S, Branson PJ, Alksne JF. Experimental model of symptomatic vasospasm in rabbits. Stroke, 1988, 19:1420-1425.
  • 4Rabinstein AA, Wijdicks EF. Cerebral vasospasm in subarachnoid hemorrhage. Curr Treat Options Neurol, 2005, 7:99-107.
  • 5Zubkov AY, Nanda A, Zhang JH. Signal transduction pathways in cerebral vasospasm. Pathophysiology, 2003, 9:47-61.
  • 6Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res, 1982, 239:57-69.
  • 7Abe K, Aoki M, Kawagoe J, et al. Ischemic delayed neuronal death: a mitochondrial hypothesis. Stroke, 1995, 26:1475-1489.
  • 8Manno EM. Subarachnoid hemorrhage. Neurol Clin, 2004, 22: 347-366.

二级参考文献11

  • 1魏伟,刘兵.中脑周围蛛网膜下腔出血32例临床分析及长期随访研究[J].中华神经外科杂志,2007,23(3):191-193. 被引量:9
  • 2Schwartz TH, Mayer SA. Quadrigeminal variant of perimesencephalic nonaneurysmal subarachnoid hemorrhage. Neurosurgery, 2000, 46:584-588.
  • 3van Gijn J, Dongen KJ, Vermeulen M, et al. Perimesencephalie hemorrhage: a nonaneurvsmal and benign form of subarachnoid hemorrhage, Neurology, 1985, 35:493-497.
  • 4Schwartz TH, Farkas J. Quadrigeminal non - aneurysmal subarachnoid hemorrhage: a true variant of perime seneephalie subarachnoid hemorrhage. Case report. Clin Neurol Neurosurg, 2003, 105:95-98.
  • 5van der Schaaf IC, Velthuis BK, Gouw A. et al. Venous drainage in perimesencephalic hemorrhage. Stroke, 2004, 35: 1614-1618.
  • 6Watanabe A, Hirano K, Kamada M, et al. Perimesencephalic nonaneurysmal subarachnoid haemorrhage and variations in the veins. Neuroradiology, 2002, 44:319-325.
  • 7lldan F, Tuna M, Erman T, et al. Prognosis and prognostic factors in nonaneurysmal perimesencephalie hemorrhage: a follow-up study in 29 patients. Surg Neurol, 2002, 57:160-166.
  • 8Alen JF, Lagares A, Lobato RD, et al. Comparison between perimeseneephalic nonaneurysmal subaraehnoid hemorrhage and subarachnoid hemorrhage caused by posterior circulation aneurysms. J Neurosurg, 2003, 98:529-535.
  • 9Taschner CA, Thines L, Lernout M, et al. Treatment decision in ruptured intraeranial aneurysms: comparison between multidetector row CT angiography and digital subtraction angiography. J Neuroradiol, 2007, 34:243-249.
  • 10Greebe P, Rinkel GJ. Life expectancy after perimesencephalic subarachnoid hemorrhage. Stroke, 2007, 38:1222-1224.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部