IL-13Rα2、VEGF和PTEN在星形细胞瘤中的表达及临床意义

Expression and clinical sionificance of IL-13Rα2,VEGF and PTEN in astrocytoma

目的:测定白细胞介素13受体α2(IL-13Rα2)、血管内皮生长因子(VEGF)和PTEN在星形细胞瘤中的表达,探讨三者与星形细胞瘤的临床病理学特征及生物学行为的关系,对预后进行评估。方法:采用免疫组化法对37例人脑星形细胞瘤石蜡标本中的IL-13Rα2、VEGF和PTEN的表达进行检测。结果:①IL-13Rα2、VEGF和PTEN在不同级别星形细胞瘤中的阳性表达率差异有统计学意义。②IL-13Rα2和VEGF的表达之间存在正相关关系,IL-13Rα2、VEGF分别与PTEN的表达之间存在负相关关系。③IL-13Rα2、VEGF和PTEN的表达在不同病人性别和肿瘤大小之间差异无统计学意义。结论:检测IL-13Rα2、VEGF和PTEN对判定肿瘤恶性程度有一定的临床意义,IL-13Rα2、VEGF和PTEN这三种因子在肿瘤发生、发展的作用机制上存在某种联系。

Objective： To determine the expression of IL-13Rα2, VEGF and PTEN inastrocytoma, to analyze the relationship among the expression of IL-13Rα2,VEGF and PTEN in astrocytoma with the clinical pathology and the biological behaviors of astrocytoma, and to evaluate the prognosis of astrocytoma. Methods： Applying SP immunohistochemical technique, Examination and statistical research were performed on the expression in 37 cases of astrocytoma. Results：（1）There was significant difference in IL-13Rα2, VEGF and PTEN expressions among the astrocytomas of different grades, （2）The expression of IL-13Rα2 was positively related to the expression of VEGF in human astrocytomas, but the expressions of IL-13Rα2 and VEGF were negatively related to the expression of PTEN in the astrocytomas. （3）The IL-13Rα2, VEGF and PTEN expressions were not significantly correlated with gender or tumor size. Conclusion： IL-13Rα2, VEGF and PTEN may serve as a biomarker of the astrocytoma malignancy and may be involved in the progression of astrocytoma. There is relationship between the expression of IL-13Rα 2, VEGF and PTEN and pathological gradation of human glioma.