Y-谷氨酰转肽酶的酶组织化学检测对胃癌及胃癌前期病变诊断意义的探讨

The Role of γ-GTP Histochemical Staining in the Diagnosis of Gastric Cancer and Precancerous Lesion

本文报道用γ-谷氨酰转肽酶(γ-GTP)酶组织化学法检测41例胃癌、28例胃粘膜不典型增生、24例胃粘膜肠上皮化生组织中γ-GTP活性。22例正常胃粘膜γ-GTP活性均呈阴性;但是41例胃癌组织中γ-GTP酶组织化学阳性率为95％,其中,高分化与中分化腺癌的γ-GTP阳性率达95％,未分化癌的阳性率则为91％,视为癌前病变的胃粘膜不典型增生和公认为胃癌前期状态的肠上皮化生组织中γ-GTP阳性率均高达96％。可见,γ-GTP酶组织化学检测对胃癌及胃癌前期病变和癌前期状态的早期诊断提供了新的比较敏感的生物化学指标。

γ-GTP activities were determined with histochemical method in 115 gastric tissue samples including 22 normal mucosa, 41 cancer tissues, 28 dysplasia and 24 intestinal metaplasia. All of the 22 normal gastric mucosa were negative for γ-GTP staining. The positive rates of γ-GTP staining were 95％ in gastric cancer, 96％ in dysplasia and 96％ in intestinal metaplasia. In view of the conception that dysplasia might be a precancerous lesion and intestinal metaplasia a precancerous condition, these findings indicate that γ-GTP may be taken as biochemical marker for diagnosis of early gastric cancer and precancerous lesions.